C₂₂H₂₅N₅O₂

Base Information

• Chemical Name: C₂₂H₂₅N₅O₂
• CAS No.: 1185281-19-9
• Molecular Formula: C₂₂H₂₅N₅O₂
• Molecular Weight: 391.473
• Mol file: 1185281-19-9.mol

Synonyms:C₂₂H₂₅N₅O₂

Chemical Property of C₂₂H₂₅N₅O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₅N₅O₂

There total 15 articles about C₂₂H₂₅N₅O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis(trichloromethyl) carbonate (32315-10-9) + 3-(5-amino-2-methylphenyl)-1,7-dimethyl-1,6-naphthyridin-2(1H)-one (1021535-31-8) + isobutyramidine (57536-10-4) → C22H25N5O2 (1185281-19-9)

Guidance literature:

bis(trichloromethyl) carbonate; 3-(5-amino-2-methylphenyl)-1,7-dimethyl-1,6-naphthyridin-2(1H)-one; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

isobutyramidine; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

2-(2-methyl-5-nitrophenyl)acetonitrile (409082-11-7) → C22H25N5O2 (1185281-19-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: water; potassium hydroxide / methanol / 14 h / Reflux

2.1: hydrogenchloride / 1,4-dioxane / 14 h / Reflux

2.2: pH > 12

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine / 1,4-dioxane; toluene / 0.17 h / 150 °C / Microwave irradiation

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

6.2: 4 h / 20 °C

With hydrogenchloride; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; triphenylphosphine; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

ethyl 6-chloro-4-(methylamino)pyridine-3-carboxylate (449811-28-3) → C22H25N5O2 (1185281-19-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 °C

1.2: 20 °C

2.1: manganese(IV) oxide / dichloromethane / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine / 1,4-dioxane; toluene / 0.17 h / 150 °C / Microwave irradiation

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

5.2: 4 h / 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;

upstream raw materials:

bis(trichloromethyl) carbonate

3-(5-amino-2-methylphenyl)-1,7-dimethyl-1,6-naphthyridin-2(1H)-one

isobutyramidine

2-(2-methyl-5-nitrophenyl)acetonitrile

Downstream raw materials:

3-(5-(3-isopropyl-1,2,4-oxadiazol-5-ylamino)-2-methylphenyl)-1,7-dimethyl-1,6-naphthyridin-2(1H)-one

Refernces