POLYURIDYLIC ACID POT. SALT, LYOPH., MR <900000*

Base Information

• Chemical Name: POLYURIDYLIC ACID POT. SALT, LYOPH., MR <900000*
• CAS No.: 27416-86-0
• Molecular Formula: C₉H₁₃N₂O₉P
• Molecular Weight: 324.184
• Mol file: 27416-86-0.mol

Synonyms:5'-Uridylic acid,polymers (8CI); Uridylic acid, homopolymer (6CI); Poly(5'-uridylic acid);Poly(U); Poly(UMP); Poly(rU); Poly(ribouridylic acid); Poly(uridylic acid)

Chemical Property of POLYURIDYLIC ACID POT. SALT, LYOPH., MR <900000*

Chemical Property:

• Melting Point: 28 °C
• Storage Temp.: −20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Polyuridylic acid potassium salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 42/43
• Safety Statements: 22-36/37

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Uses: Polyuridylic acid potassium salt, a homopolymer of uridine, is used as a single-stranded RNA model compound often in comparison with other ssRNA model oligonucleotides such as Poly(I) and Poly(C) to study processes that are dependent upon ssRNA regulation such as Toll-like receptor regulation.

Technology Process of POLYURIDYLIC ACID POT. SALT, LYOPH., MR <900000*

There total 82 articles about POLYURIDYLIC ACID POT. SALT, LYOPH., MR <900000* which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

yeast RNA → cytidine monophosphate (63-37-6,30811-80-4) + 5'-Uridylic Acid (58-97-9,27416-86-0) + 5'-adenosine monophosphate (61-19-8,24937-83-5,67583-85-1) + Guanosine 5'-monophosphate (85-32-5)

Guidance literature:

With barley roots 5'-phosphodiesterase; at 70 ℃; for 0.5h; pH=5; aq. acetate buffer; Enzymatic reaction;

Reference yield:

A(2'p5'A)3'p5'U → 5'-Uridylic Acid (58-97-9,27416-86-0) + 5'-adenosine monophosphate (61-19-8,24937-83-5,67583-85-1)

Guidance literature:

With SVP (1 unit); In water; at 37 ℃; for 12h; Product distribution; HPLC analysis; no reaction with RNaseT₂ or spleen phosphodiesterase;

DOI:10.1016/0040-4020(95)00590-5

Reference yield:

A(2'p5'G)3'p5'U → 5'-Uridylic Acid (58-97-9,27416-86-0) + 5'-adenosine monophosphate (61-19-8,24937-83-5,67583-85-1) + Guanosine 5'-monophosphate (85-32-5)

Guidance literature:

With SVP (1 unit); In water; at 37 ℃; for 12h; Product distribution; HPLC analysis; no reaction with RNaseT₂ or spleen phosphodiesterase;

DOI:10.1016/0040-4020(95)00590-5

upstream raw materials:

2',3'-O-isopropylideneuridine

orotic acid

(R)-2',3'-O-benzylideneuridine

5-phosphoribosyl-1-pyrophosphate

Downstream raw materials:

5-Brom-uridin-5'-phosphat

uridine 3',5'-cyclic monophosphate

uridine 5'-(2-amino-2-deoxy-α-D-galactopyranosyl diphosphate)

uridine 5’-monophosphate-imidazole

Refernces

• 1、 Desai, Bijoy J.,Wood, B. McKay,Fedorov, Alexander A.,Fedorov, Elena V.,Goryanova, Bogdana,Amyes, Tina L.,Richard, John P.,Almo, Steven C.,Gerlt, John A.. "Conformational changes in orotidine 5′-monophosphate decarboxylase: A structure-based explanation for how the 5′-phosphate group activates the enzyme". . p. 8665 - 8678. Retrieved 2012.
• 2、 Ginsburg-Shmuel, Tamar,Haas, Michael,Grbic, Djordje,Arguin, Guillaume,Nadel, Yael,Gendron, Fernand-Pierre,Reiser, Georg,Fischer, Bilha. "UDP made a highly promising stable, potent, and selective P2Y6-receptor agonist upon introduction of a boranophosphate moiety". . p. 5483 - 5495. Retrieved 2012.
• 3、 Toth, Krisztina,Amyes, Tina L.,Wood, Bryant M.,Chan, Kui,Gerlt, John A.,Richard, John P.. "Product deuterium isotope effect for orotidine 5′-monophosphate decarboxylase: Evidence for the existence of a short-lived carbanion intermediate". . p. 12946 - 12947. Retrieved 2007.
• 4、 Chambers. "-". . p. 3032,3033. Retrieved 1959.
• 5、 Duca, Maria,Trindle, Carl O.,Hecht, Sidney M.. "Structural basis for the exceptional stability of bisaminoacylated nucleotides and transfer RNAs". . p. 11368 - 11377. Retrieved 2011.
• 6、 Iiams, Vanessa,Desai, Bijoy J.,Fedorov, Alexander A.,Fedorov, Elena V.,Almo, Steven C.,Gerlt, John A.. "Mechanism of the orotidine 5′-monophosphate decarboxylase-catalyzed reaction: Importance of residues in the orotate binding site". . p. 8497 - 8507. Retrieved 2011.
• 7、 Nunez,Barker. "". . p. 3843. Retrieved 1976.
• 8、 Kang, Minhee,Doddapaneni, Kiran,Sarni, Samantha,Heppner, Zach,Wysocki, Vicki,Wu, Zhengrong. "Solution structure of the nucleotide hydrolase BlsM: Implication of its substrate specificity". . p. 1760 - 1773. Retrieved 2020.
• 9、 Gulland,Smith. "-". . p. 338,340. Retrieved 1947.
• 10、 Nakajima, Kazuki,Kizuka, Yasuhiko,Yamaguchi, Yoshiki,Hirabayashi, Yoshio,Takahashi, Kazuo,Yuzawa, Yukio,Taniguchi, Naoyuki. "Identification and characterization of UDP-mannose in human cell lines and mouse organs: Differential distribution across brain regions and organs". . p. 401 - 407. Retrieved 2018.