Technology Process of 3-(2-(2-aminopyrimidin-5-yl)ethynyl)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide
There total 5 articles about 3-(2-(2-aminopyrimidin-5-yl)ethynyl)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
copper(l) iodide; palladium diacetate; N-ethyl-N,N-diisopropylamine; tricyclohexylphosphine;
In
N,N-dimethyl-formamide;
at 60 ℃;
Sealed tube;
Inert atmosphere;
DOI:10.1016/j.bmcl.2015.07.006
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: thionyl chloride / N,N-dimethyl-formamide / 2 h / Reflux
2.1: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C
3.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; triethylamine; copper(l) iodide / acetonitrile / 2 h / 80 °C / Sealed tube; Inert atmosphere
3.2: 3 h / 20 °C
4.1: palladium diacetate; tricyclohexylphosphine; N-ethyl-N,N-diisopropylamine; copper(l) iodide / N,N-dimethyl-formamide / 60 °C / Sealed tube; Inert atmosphere
With
copper(l) iodide; thionyl chloride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; palladium diacetate; triethylamine; N-ethyl-N,N-diisopropylamine; tricyclohexylphosphine;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
3.1: |Sonogashira Cross-Coupling / 4.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmcl.2015.07.006
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / tetrahydrofuran / 1 h / 0 - 20 °C
2.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; triethylamine; copper(l) iodide / acetonitrile / 2 h / 80 °C / Sealed tube; Inert atmosphere
2.2: 3 h / 20 °C
3.1: palladium diacetate; tricyclohexylphosphine; N-ethyl-N,N-diisopropylamine; copper(l) iodide / N,N-dimethyl-formamide / 60 °C / Sealed tube; Inert atmosphere
With
copper(l) iodide; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; palladium diacetate; triethylamine; N-ethyl-N,N-diisopropylamine; tricyclohexylphosphine;
In
tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
2.1: |Sonogashira Cross-Coupling / 3.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmcl.2015.07.006