Technology Process of benzhydryl clavulanate
There total 4 articles about benzhydryl clavulanate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
tetrahydrofuran;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 70 percent / sodium hydroxide / H2O / 1.17 h / 0 °C
2: 69 percent / dimethylformamide / 1.5 h / Ambient temperature
3: 84 percent / H2 / palladium on carbon / ethanol / 0.75 h / 760 Torr / Ambient temperature
4: 60 percent / tetrahydrofuran / Ambient temperature
With
sodium hydroxide; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 69 percent / dimethylformamide / 1.5 h / Ambient temperature
2: 84 percent / H2 / palladium on carbon / ethanol / 0.75 h / 760 Torr / Ambient temperature
3: 60 percent / tetrahydrofuran / Ambient temperature
With
hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
