epi-cholesteryl (R)-2-(3-benzoylphenyl)propionate

Base Information

• Chemical Name: epi-cholesteryl (R)-2-(3-benzoylphenyl)propionate
• CAS No.: 913843-20-6
• Molecular Formula: C₄₃H₅₈O₃
• Molecular Weight: 622.932
• Mol file: 913843-20-6.mol

Synonyms:epi-cholesteryl (R)-2-(3-benzoylphenyl)propionate

Chemical Property of epi-cholesteryl (R)-2-(3-benzoylphenyl)propionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of epi-cholesteryl (R)-2-(3-benzoylphenyl)propionate

There total 3 articles about epi-cholesteryl (R)-2-(3-benzoylphenyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

epicholesterol (474-77-1) + R-ketoprofen (56105-81-8,22161-86-0) → epi-cholesteryl (R)-2-(3-benzoylphenyl)propionate (913843-20-6)

Guidance literature:

R-ketoprofen; With dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 0.5h;

epicholesterol; With dmap; In dichloromethane; at 0 ℃; for 8h;

DOI:10.1021/ol061854c

Reference yield:

Chloro-acetic acid (8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester (910899-79-5) → epi-cholesteryl (R)-2-(3-benzoylphenyl)propionate (913843-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 398 mg / MeOH; K₂CO₃ / 1 h / Heating

2.1: dicyclohexylcarbodiimide / CH₂Cl₂ / 0.5 h / 0 °C

2.2: 74 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 8 h / 0 °C

With methanol; potassium carbonate; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1021/ol061854c

Reference yield:

cholesterol (57-88-5) + R-ketoprofen (56105-81-8,22161-86-0) → epi-cholesteryl (R)-2-(3-benzoylphenyl)propionate (913843-20-6)

Guidance literature:

DOI:10.1021/ol061854c

upstream raw materials:

epicholesterol

R-ketoprofen

cholesterol

Chloro-acetic acid (8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Refernces