(2R)-2-(3-benzoylphenyl)propanoic acid

Base Information

• Chemical Name: (2R)-2-(3-benzoylphenyl)propanoic acid
• CAS No.: 56105-81-8
• Molecular Formula: C16H14O3
• Molecular Weight: 254.285
• Hs Code.: 2918300090
• Mol file: 56105-81-8.mol

Synonyms:Benzeneaceticacid, 3-benzoyl-a-methyl-,(R)-;(-)-2-(3-Benzoylphenyl)propionic acid;(-)-3-Benzoyl-a-methylbenzeneacetic acid;(-)-Ketoprofen;(2R)-2-(3-Benzoylphenyl)propionic acid;(R)-(-)-Ketoprofen;(R)-2-(3-Benzoylphenyl)propionic acid;(R)-3-Benzoyl-a-methylphenylacetic acid;(R)-Ketoprofen;(R)-Ketoprophen;

Chemical Property of (2R)-2-(3-benzoylphenyl)propanoic acid

Chemical Property:

• Vapor Pressure: 3.32E-08mmHg at 25°C
• Melting Point: 77-78 °C
• Refractive Index: 1.591
• Boiling Point: 431.316 °C at 760 mmHg
• PKA: 4.23±0.10(Predicted)
• Flash Point: 228.793 °C
• PSA: 54.37000
• Density: 1.198g/cm³
• LogP: 3.10570

Purity/Quality:

99% ^*data from raw suppliers

(R)-(-)-Ketoprofen ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Anti-inflammatory; analgesic.

Technology Process of (2R)-2-(3-benzoylphenyl)propanoic acid

There total 29 articles about (2R)-2-(3-benzoylphenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

C16H14O3*C17H21NO2 → R-ketoprofen (56105-81-8,22161-86-0)

Guidance literature:

With hydrogenchloride; In water; at 10 - 35 ℃;

Reference yield: 90.0%

(RS)-ketoprofen vinyl ester (855519-35-6) → (S)-ketoprofen vinyl ester (911412-01-6) + R-ketoprofen (56105-81-8,22161-86-0)

Guidance literature:

With immobilized Lipozyme; In 1,4-dioxane; water; at 25 ℃; for 96h; optical yield given as %ee; Enzymatic reaction;

DOI:10.1016/j.bmc.2009.01.040

Reference yield: 85.0%

(R)-2-(3-Benzoyl-phenyl)-propionic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester (156994-73-9) → R-ketoprofen (56105-81-8,22161-86-0)

Guidance literature:

With sodium carbonate; In methanol; water; for 2h; Ambient temperature;

DOI:10.1016/S0040-4020(01)81339-9

upstream raw materials:

ketoprofen methyl ester

ketoprofen

(+)-α-(3-benzylphenyl)propionic acid

α-(3-benzoylphenyl)acrylic acid

Downstream raw materials:

epi-cholesteryl (R)-2-(3-benzoylphenyl)propionate

3-ethylbenzophenone

C₂₂H₁₉NO₂

(R)-Ketoprofenoyl-CoA

Refernces

• 1、 Hellinghausen, Garrett,Lopez, Diego A.,Lee, Jauh T.,Wang, Yadi,Weatherly, Choyce A.,Portillo, Abiud E.,Berthod, Alain,Armstrong, Daniel W.. "Evaluation of the Edman degradation product of vancomycin bonded to core-shell particles as a new HPLC chiral stationary phase". . p. 1067 - 1078. Retrieved 2018/08/01.
• 2、 Kucerova, Gabriela,Kalikova, Kveta,Tesarova, Eva. "Enantioselective potential of polysaccharide-based chiral stationary phases in supercritical fluid chromatography". supporting information. p. 239 - 246. Retrieved 2017/05/29.