Benzeneacetic acid, 3-benzoyl-a-methyl-, ethenyl ester

Base Information

• Chemical Name: Benzeneacetic acid, 3-benzoyl-a-methyl-, ethenyl ester
• CAS No.: 855519-35-6
• Molecular Formula: C18H16O3
• Molecular Weight: 280.323
• Mol file: 855519-35-6.mol

Synonyms:

Chemical Property of Benzeneacetic acid, 3-benzoyl-a-methyl-, ethenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneacetic acid, 3-benzoyl-a-methyl-, ethenyl ester

There total 1 articles about Benzeneacetic acid, 3-benzoyl-a-methyl-, ethenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

vinyl acetate (108-05-4,9003-20-7) + ketoprofen (22071-15-4,22161-86-0) → (RS)-ketoprofen vinyl ester (855519-35-6)

Guidance literature:

vinyl acetate; ketoprofen; With mercury(II) diacetate; at 20 ℃; for 0.5h;

With sulfuric acid; for 6h; Reflux;

DOI:10.1016/j.bmc.2009.01.040

Reference yield: 90.0%

(RS)-ketoprofen vinyl ester (855519-35-6) → (S)-ketoprofen vinyl ester (911412-01-6) + R-ketoprofen (56105-81-8,22161-86-0)

Guidance literature:

With immobilized Lipozyme; In 1,4-dioxane; water; at 25 ℃; for 96h; optical yield given as %ee; Enzymatic reaction;

DOI:10.1016/j.bmc.2009.01.040

Reference yield: 48.5%

(RS)-ketoprofen vinyl ester (855519-35-6) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 1-O-ketoprofen glycerol ester (1257296-76-6)

Guidance literature:

With lipase acrylic resin from Candida antarctica; In acetone; at 70 ℃; for 12h; Molecular sieve; Enzymatic reaction;

DOI:10.1021/bm100712k

upstream raw materials:

vinyl acetate

ketoprofen

Downstream raw materials:

(S)-ketoprofen vinyl ester

R-ketoprofen

1-O-ketoprofen glycerol ester

Refernces