(R)-Ketoprofenoyl-CoA

Base Information

• Chemical Name: (R)-Ketoprofenoyl-CoA
• CAS No.: 430438-74-7
• Molecular Formula: C₃₇H₄₈N₇O₁₈P₃S
• Molecular Weight: 1003.81
• Mol file: 430438-74-7.mol

Synonyms:(R)-Ketoprofenoyl-CoA

Chemical Property of (R)-Ketoprofenoyl-CoA

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-Ketoprofenoyl-CoA

There total 4 articles about (R)-Ketoprofenoyl-CoA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ketoprofen (22071-15-4,22161-86-0) + coenzyme A (85-61-0) → (R)-Ketoprofenoyl-CoA (430438-74-7) + S-ketoprofen (22161-81-5,22161-86-0)

Guidance literature:

With adenylate kinase; pyruvate kinase; phosphoenolpyruvic acid; recombinant Luciola lateralis luciferase; ATP; NADH; magnesium chloride; lactate dehydrogenase; at 27 ℃; pH=7; enantioselective reaction; aq. potassium phosphate buffer; Enzymatic reaction;

DOI:10.1016/j.molcatb.2011.01.008

Reference yield:

2-methyl-2-(3-benzoylphenyl)malonic acid (150360-24-0) → (R)-Ketoprofenoyl-CoA (430438-74-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Mesorhizobium sp. BNC₁ arylmalonate decarboxylase / Enzymatic reaction

2: adenylate kinase; pyruvate kinase; recombinant Luciola lateralis luciferase; phosphoenolpyruvic acid; ATP; NADH; magnesium chloride; lactate dehydrogenase / 27 °C / pH 7 / aq. potassium phosphate buffer; Enzymatic reaction

With adenylate kinase; pyruvate kinase; phosphoenolpyruvic acid; Mesorhizobium sp. BNC₁ arylmalonate decarboxylase; recombinant Luciola lateralis luciferase; ATP; NADH; magnesium chloride; lactate dehydrogenase;

DOI:10.1016/j.molcatb.2011.01.008

Reference yield:

ketoprofen (22071-15-4,22161-86-0) + coenzyme A (85-61-0) → (S)-Ketoprofenoyl-CoA (430438-75-8) + (R)-Ketoprofenoyl-CoA (430438-74-7)

Guidance literature:

With recombinant luciferase from Pyrocoelia miyako, firefly; ATP; enantioselective reaction; aq. buffer; Enzymatic reaction;

DOI:10.1271/bbb.110299

upstream raw materials:

2-methyl-2-(3-benzoylphenyl)malonic acid

ketoprofen

coenzyme A

R-ketoprofen

Refernces

• 1、 Kato, Dai-Ichiro,Yokoyama, Keisuke,Hiraishi, Yoshihiro,Takeo, Masahiro,Negoro, Seiji. "Comparison of acyl-CoA synthetic activities and enantioselectivity toward 2-arylpropanoic acids in firefly luciferases". experimental part. p. 1758 - 1762. Retrieved 2012/02/02.