2-(Trifluoromethyl)phenylhydrazine

Base Information

• Chemical Name: 2-(Trifluoromethyl)phenylhydrazine
• CAS No.: 365-34-4
• Molecular Formula: C7H7F3N2
• Molecular Weight: 176.141
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID70334460
• Nikkaji Number: J308.977K
• Wikidata: Q82100272
• ChEMBL ID: CHEMBL1621897
• Mol file: 365-34-4.mol

Synonyms:2-(Trifluoromethyl)phenylhydrazine;365-34-4;(2-(Trifluoromethyl)phenyl)hydrazine;[2-(trifluoromethyl)phenyl]hydrazine;2-Trifluoromethylphenylhydrazine;MFCD00052687;1-[2-(Trifluoromethyl)phenyl]hydrazine;Hydrazine, [2-(trifluoromethyl)phenyl]-;m-Trifluoromethylphenylhydrazine;1-(2-(trifluoromethyl)phenyl)hydrazine;o-trifluoromethylphenylhydrazine;Enamine_002408;SCHEMBL358811;o-trifluoromethyl-phenylhydrazine;2-trifluoromethyl-phenylhydrazine;2-trifluoromethylphenyl hydrazine;CHEMBL1621897;DTXSID70334460;2-trifluoromethyl-phenyl-hydrazine;BUTTPARK 44\57-17;HMS1400N10;(2-(trifluoromethyl)phenylhydrazine;2-(trifluoromethyl)-phenylhydrazine;2-(trifluoromethyl)phenyl hydrazine;AMY31590;[o-(Trifluoromethyl)phenyl]hydrazine;(2-trifluoromethyl-phenyl)-hydrazine;BBL022184;STK894826;AKOS000268850;AC-1497;2-(Trifluoromethyl)phenylhydrazine, 97%;PS-10339;1-[2-(Trifluoromethyl)phenyl]hydrazine #;BB 0219959;CS-0204844;FT-0608974;A823285

Chemical Property of 2-(Trifluoromethyl)phenylhydrazine

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 260mmHg at 25°C
• Melting Point: 55-58 °C
• Refractive Index: 1.507
• Boiling Point: 221.5 °C at 760 mmHg
• PKA: 4.34±0.10(Predicted)
• Flash Point: 87.7 °C
• PSA: 38.05000
• Density: 1.359 g/cm³
• LogP: 2.76430
• Water Solubility.: Insoluble in water.
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 176.05613272
• Heavy Atom Count: 12
• Complexity: 146

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Trifluoromethyl)phenylhydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 26-36/37/39-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(F)(F)F)NN
• Uses: 2-(Trifluoromethyl)phenylhydrazine is used as an intermediate in organic syntheses. It is also ued as a fine chemical intermediate, GC derivatizing agent, coupling reagent and N- protecting agent.

Technology Process of 2-(Trifluoromethyl)phenylhydrazine

There total 6 articles about 2-(Trifluoromethyl)phenylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-acetyl-3-trifluoromethylbenzenamine (351-36-0) → 2-(trifluoromethyl)phenylhydrazine (365-34-4)

Guidance literature:

Multi-step reaction with 5 steps

1: HNO₃, H₂SO₄

2: aq. H₂SO₄

3: (i) H₂SO₄, EtNO₂, EtOH, (ii) Cu

4: H₂ / Raney-Ni / petroleum ether

5: (i) NaNO₂, aq. HCl, (ii) NH₃, SO₂

With sulfuric acid; hydrogen; nitric acid; nickel; In Petroleum ether;

DOI:10.1016/S0040-4020(01)93332-0

Reference yield:

2-nitrobenzotrifluoride (384-22-5) → 2-(trifluoromethyl)phenylhydrazine (365-34-4)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Raney-Ni / petroleum ether

2: (i) NaNO₂, aq. HCl, (ii) NH₃, SO₂

With hydrogen; nickel; In Petroleum ether;

DOI:10.1016/S0040-4020(01)93332-0

Reference yield:

4-nitro-3-(trifluoromethyl)benzeneamine (393-11-3) → 2-(trifluoromethyl)phenylhydrazine (365-34-4)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) H₂SO₄, EtNO₂, EtOH, (ii) Cu

2: H₂ / Raney-Ni / petroleum ether

3: (i) NaNO₂, aq. HCl, (ii) NH₃, SO₂

With hydrogen; nickel; In Petroleum ether;

DOI:10.1016/S0040-4020(01)93332-0

upstream raw materials:

2-(trifluoromethyl)benzenamine

o-trifluoromethylbenzene diazonium chloride

2-nitrobenzotrifluoride

N-acetyl-3-trifluoromethylbenzenamine

Downstream raw materials:

C₉H₁₀F₃N₃O

3-[(2-Trifluoromethyl-phenyl)-hydrazono]-piperidin-2-one

5-n-butyl-2,4-dihydro-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one

5-(3,6-Dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-1H-indole-2,3-dione 3-[(2-trifluoromethyl) phenylhydrazone]

Refernces

• 1、 Nagarajan, K.,Talwalker, P.K.,Kulkarni, C.L.,Venkateswarlu, A.,Prabhu, S.S.,Nayak, G.V.. "Antiimplantation Agents: Part I - 1-Arylthiosemicarbazides". . p. 1243 - 1257. Retrieved 2007/10/02.
• 2、 Fujii,Cook. "Probiotics. Antistaphylococcal and antifibrinolytic activities of ω guanidino acids and ω guanidinoacyl L histidines". . p. 1409 - 1411. Retrieved 2007/10/04.