2,5-dichloro-4-fluoroacetanilide

Base Information

• Chemical Name: 2,5-dichloro-4-fluoroacetanilide
• CAS No.: 398-91-4
• Molecular Formula: C₈H₆Cl₂FNO
• Molecular Weight: 222.046
• Mol file: 398-91-4.mol

Synonyms:2,5-dichloro-4-fluoroacetanilide

Chemical Property of 2,5-dichloro-4-fluoroacetanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-dichloro-4-fluoroacetanilide

There total 2 articles about 2,5-dichloro-4-fluoroacetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

Oxim d. 2,5-Dichlor-5-fluor-acetophenons (708-59-8) → 2,5-dichloro-4-fluoroacetanilide (398-91-4)

Guidance literature:

Oxim d. 2,5-Dichlor-5-fluor-acetophenons; With bis(trichloromethyl) carbonate; N,N-dimethyl-formamide; In acetonitrile; for 3h; Reflux;

With water; sodium hydrogencarbonate; In acetonitrile;

DOI:10.1080/00304940809458118

Reference yield: 37.0%

4'-fluoroacetanilide (351-83-7) → N-(3-chloro-4-fluorophenyl)acetamide (877-90-7) + 2,3-dichloro-4-fluoroacetanilide (36556-53-3) + 2,5-dichloro-4-fluoroacetanilide (398-91-4)

Guidance literature:

With hydrogen fluoride; antimony pentafluoride; sodium chloride; at -20 ℃; for 2h;

DOI:10.1002/chem.202000902

upstream raw materials:

Oxim d. 2,5-Dichlor-5-fluor-acetophenons

4'-fluoroacetanilide

Refernces

• 1、 Su,Zhang,Li,Li. "A simple and efficient procedure for the Beckmann rearrangement of oxtme using bis-(Trichloromethyl) carbonate/DMF". experimental part. p. 543 - 550. Retrieved 2009/04/05.