4-Methoxyamphetamine

Base Information

• Chemical Name: 4-Methoxyamphetamine
• CAS No.: 64-13-1
• Deprecated CAS: 23239-32-9
• Molecular Formula: C10H15 N O
• Molecular Weight: 165.235
• Hs Code.: 2922299090
• European Community (EC) Number: 200-577-0
• NSC Number: 32757
• UNII: OVB8F8P39Q
• DSSTox Substance ID: DTXSID7040578
• Nikkaji Number: J213.549C
• Wikipedia: Para-Methoxyamphetamine
• Wikidata: Q230005
• Metabolomics Workbench ID: 130011
• ChEMBL ID: CHEMBL278663
• Mol file: 64-13-1.mol

Synonyms:4-methoxyamphetamine;4-methoxyamphetamine hydrochloride;4-methoxyamphetamine hydrochloride, (+-)-isomer;4-methoxyamphetamine hydrochloride, (R)-isomer;4-methoxyamphetamine hydrochloride, (S)-isomer;4-methoxyamphetamine sulfate;4-methoxyamphetamine, (+-)-isomer;4-methoxyamphetamine, (R)-isomer;4-methoxyamphetamine, (S)-isomer;p-methoxy-alpha-methylphenethylamine;p-methoxyamphetamine;para-methoxyamphetamine;paramethoxyamphetamine

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of 4-Methoxyamphetamine

Chemical Property:

• Vapor Pressure: 0.0139mmHg at 25°C
• Refractive Index: 1.518
• Boiling Point: 258.2°C at 760 mmHg
• PKA: 10.00±0.10(Predicted)
• Flash Point: 107.5°C
• PSA: 35.25000
• Density: 0.99g/cm³
• LogP: 2.28520
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 165.115364102
• Heavy Atom Count: 12
• Complexity: 119

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC=C(C=C1)OC)N

Technology Process of 4-Methoxyamphetamine

There total 34 articles about 4-Methoxyamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

E-1-(4'-methoxyphenyl)prop-1-ene (4180-23-8,25086-72-0,63589-56-0) → 2-amino-1-(4-methyoxyphenyl)propane (64-13-1,23239-32-9)

Guidance literature:

With benzene-1,3-dicarbonitrile; 1,3,5-triphenylbenzene; In water; acetonitrile; Product distribution; Irradiation; further reagents;

DOI:10.1016/S0040-4039(00)60695-0

Reference yield: 86.0%

4-(2-nitro-propenyl)-anisole (17354-63-1) → 2-amino-1-(4-methyoxyphenyl)propane (64-13-1,23239-32-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 3h; Inert atmosphere; Reflux;

DOI:10.1039/c1ob06251d

Reference yield: 82.0%

1-methoxy-4-((E)-2-nitroprop-1-enyl)benzene (37629-51-9) → 2-amino-1-(4-methyoxyphenyl)propane (64-13-1,23239-32-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 3h; Inert atmosphere; Reflux;

DOI:10.1021/acs.jmedchem.8b00052

upstream raw materials:

1-methoxy-4-((E)-2-nitroprop-1-enyl)benzene

1-(2-chloropropyl)-4-methoxybenzene

1-anisyl-1-hydrazonoethane

4-methoxyphenylacetone oxime

Downstream raw materials:

2-(4-methoxy-phenyl)-1-methyl-ethyl isocyanate

cyclopentyl-[2-(4-methoxy-phenyl)-1-methyl-ethyl]-amine

N-ethyl-p-methoxy-a-methyl-Phenethylamine

N-[2-(4-Methoxy-phenyl)-1-methyl-ethyl]-acetamide

Refernces

• 1、 Albarrán-Velo, Jesús,Gotor-Fernández, Vicente,Lavandera, Iván. "Markovnikov Wacker-Tsuji Oxidation of Allyl(hetero)arenes and Application in a One-Pot Photo-Metal-Biocatalytic Approach to Enantioenriched Amines and Alcohols". . p. 4096 - 4108. Retrieved 2021/08/19.
• 2、 Cui, Zhibing,Liu, Jianguo,Liu, Qiying,Ma, Longlong,Singh, Thishana,Wang, Chenguang,Wang, Nan,Zhu, Yuting. "Facile synthesis of controllable graphene-co-shelled reusable Ni/NiO nanoparticles and their application in the synthesis of amines under mild conditions". supporting information. p. 7387 - 7397. Retrieved 2020/11/19.