N-PHENYL-4-QUINAZOLINAMINE

Base Information

• Chemical Name: N-PHENYL-4-QUINAZOLINAMINE
• CAS No.: 34923-95-0
• Molecular Formula: C14H11 N3
• Molecular Weight: 221.261
• Mol file: 34923-95-0.mol

Synonyms:Quinazoline,4-anilino- (6CI,7CI); 4-(N-Phenylamino)quinazoline; 4-Anilinoquinazoline; NSC288013; Phenyl(quinazolin-4-yl)amine

Chemical Property of N-PHENYL-4-QUINAZOLINAMINE

Chemical Property:

• Vapor Pressure: 3.64E-06mmHg at 25°C
• Boiling Point: 386.1°Cat760mmHg
• Flash Point: 187.3°C
• PSA: 37.81000
• Density: 1.256g/cm³
• LogP: 3.44640

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-PHENYL-4-QUINAZOLINAMINE

There total 19 articles about N-PHENYL-4-QUINAZOLINAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

anthranilic acid amide (28144-70-9,88-68-6) + orthoformic acid triethyl ester (122-51-0) + aniline (62-53-3) → 4-Hydroxyquinazoline (491-36-1) + 4-(phenylamino)quinazoline (34923-95-0)

Guidance literature:

With H₆[PMo₉V₃O₄₀]; In acetonitrile; for 2h; Reflux;

DOI:10.1016/j.tetlet.2008.12.044

Reference yield: 90.2%

4-N-phenylaminoquinazoline-2-(1H)thione (35696-83-4) → 4-(phenylamino)quinazoline (34923-95-0)

Guidance literature:

With nickel; In methanol; for 6h; Heating;

DOI:10.1055/s-2004-815949

Reference yield: 89.7%

N'-(2-cyanophenyl)-N,N-dimethylimidoformamide (36185-83-8) + aniline (62-53-3) → 4-(phenylamino)quinazoline (34923-95-0)

Guidance literature:

With acetic acid; for 3h; Reflux;

DOI:10.1016/j.tet.2013.12.028

upstream raw materials:

4-chloroquinazoline

aniline

formic acid

2-amino-N′-phenylbenzamidine

Refernces

• 1、 Heravi, Majid M.,Sadjadi, Samaheh,Mokhtari Haj, Negar,Oskooie, Hossein A.,Shoar, Rahim. Hekmat,Bamoharram, Fatemeh F.. "A novel multi-component synthesis of 4-arylaminoquinazolines". . p. 943 - 945. Retrieved 2009.
• 2、 Krapf, Michael K.,Gallus, Jennifer,Spindler, Anna,Wiese, Michael. "Synthesis and biological evaluation of quinazoline derivatives – A SAR study of novel inhibitors of ABCG2". . p. 506 - 525. Retrieved 2018/11/06.
• 3、 Wang, Zheng,Wang, Cuiling,Sun, Yanni,Zhang, Ning,Liu, Zhulan,Liu, Jianli. "A novel strategy to the synthesis of 4-anilinoquinazoline derivatives". . p. 906 - 913. Retrieved 2014/01/23.