Naproxcinod

Base Information Edit

Chemical Name:Naproxcinod
CAS No.:163133-43-5
Molecular Formula:C18H21NO6
Molecular Weight:347.368
Hs Code.:
European Community (EC) Number:864-298-1
UNII:V24GR4LI3I
DSSTox Substance ID:DTXSID20167523
Wikipedia:Naproxcinod
Wikidata:Q3335996
NCI Thesaurus Code:C83989
Metabolomics Workbench ID:149896
ChEMBL ID:CHEMBL2103831
Mol file:163133-43-5.mol

Synonyms:4-(nitrooxy)butyl-(2S)-2-(6-methoxy-2-naphthyl)propanoate;AZD 3582;AZD-3582;AZD3582;Naproxcinod;naproxen-n-butyl nitrate;NicOx;nitric oxide naproxen;nitric oxide-releasing naproxen;NO-naproxen

Suppliers and Price of Naproxcinod

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 47 raw suppliers

Chemical Property of Naproxcinod Edit

Chemical Property:

Boiling Point:489.475 °C at 760 mmHg
Flash Point:193.208 °C
PSA：90.58000
Density:1.213 g/cm³
LogP:4.00680
XLogP3:4.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:347.13688739
Heavy Atom Count:25
Complexity:438

Purity/Quality:: 98%,99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)OCCCCO[N+](=O)[O-]
Isomeric SMILES:C[C@@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)OCCCCO[N+](=O)[O-]
Recent ClinicalTrials:A Phase II Trial of Calcitriol and Naproxen in Patients With Recurrent Prostate Cancer
Recent EU Clinical Trials:A 13-Week, Phase 3, Multicenter, Randomized, Parallel-Group, Double-Blind, Placebo bid and Naproxen 500 mg bid, Controlled Study on the Efficacy on Signs and Symptoms, and Safety of Naproxcinod (HCT 3012) 750 mg bid, in Patients with Osteoarthritis of the Hip

Technology Process of Naproxcinod

There total 16 articles about Naproxcinod which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.8%