Propyl methanesulfonate

Base Information

• Chemical Name: Propyl methanesulfonate
• CAS No.: 1912-31-8
• Molecular Formula: C4H10 O3 S
• Molecular Weight: 138.188
• Hs Code.: 2905199090
• European Community (EC) Number: 217-619-9
• NSC Number: 49872
• UNII: 9M6NKT0B5H
• DSSTox Substance ID: DTXSID4031770
• Nikkaji Number: J3.381B
• Wikidata: Q27272731
• Mol file: 1912-31-8.mol

Synonyms:methanesulfonic acid, propyl ester;n-propyl methane sulfonate;propyl methanesulfonate

Chemical Property of Propyl methanesulfonate

Chemical Property:

• Vapor Pressure: 0.106mmHg at 25°C
• Refractive Index: 1.4200 to 1.4250
• Boiling Point: 229.2°Cat760mmHg
• Flash Point: 92.4°C
• PSA: 51.75000
• Density: 1.133g/cm³
• LogP: 1.45340
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 138.03506535
• Heavy Atom Count: 8
• Complexity: 130

Purity/Quality:

99% ^*data from raw suppliers

Propyl Methanesulfonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCOS(=O)(=O)C

Technology Process of Propyl methanesulfonate

There total 5 articles about Propyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

propan-1-ol (71-23-8) + methanesulfonyl chloride (124-63-0) → propyl methanesulfonate (1912-31-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;

Reference yield: 85.0%

trimethyl(propoxy)silane (1825-63-4) + methanesulfonyl chloride (124-63-0) → propyl methanesulfonate (1912-31-8)

Guidance literature:

With FeCl₃-Montmorillonite K-10; In acetonitrile; for 3h; Heating;

DOI:10.1515/znb-2005-0711

Reference yield: 83.0%

2-propoxy-tetrahydro-pyran (6581-64-2) + methanesulfonyl chloride (124-63-0) → propyl methanesulfonate (1912-31-8)

Guidance literature:

With FeCl₃-Montmorillonite K-10; In acetonitrile; for 2h; Heating;

DOI:10.1515/znb-2005-0711

upstream raw materials:

propan-1-ol

methanesulfonyl chloride

carbon dioxide

Methanesulfonic anhydride

Downstream raw materials:

n-propyl hydroperoxide

trans-4-Decen

[6-methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophen-3-yl]-[4-(4-propyl-piperazin-1-yl)-phenyl]-methanone

2-hexadecanoylamino-3-(4-propoxy-phenyl)-propionic acid methyl ester

Refernces

• 1、 Aydin, Busra O.,Anil, Derya,Demir, Yeliz. "Synthesis of N-alkylated pyrazolo[3,4-d]pyrimidine analogs and evaluation of acetylcholinesterase and carbonic anhydrase inhibition properties". . . Retrieved 2021/02/01.
• 2、 -. "HETEROCYCLIC NON-PEPTIDE GNRH ANTAGONISTS". Page/Page column 68-69. . Retrieved 2008/06/13.