Poly-4-dioxan-2-one

Base Information

• Chemical Name: Poly-4-dioxan-2-one
• CAS No.: 29223-92-5
• Molecular Formula: C4H6O3
• Molecular Weight: 102.08864
• Hs Code.: 3907998090
• Mol file: 29223-92-5.mol

Synonyms:poly-4-dioxan-2-one

Chemical Property of Poly-4-dioxan-2-one

Chemical Property:

• Melting Point: 114°C (experimental)
• Boiling Point: 222.9°Cat760mmHg
• Flash Point: 85.5°C
• Density: 1.2g/cm³
• Storage Temp.: ?20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Poly(dioxanone) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: PDO is widely used as a monofilament wound suture. PDO/elastin-based blends prepared by electrospinning may be used as cardiovascular grafts.

Technology Process of Poly-4-dioxan-2-one

There total 18 articles about Poly-4-dioxan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diethylene glycol (111-46-6) → p-dioxanone (3041-16-5,29223-92-5)

Guidance literature:

With pyridine; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; In acetonitrile; Inert atmosphere;

DOI:10.1055/s-0032-1317018

Reference yield: 90.0%

diethylene glycol (111-46-6) → 1,4-dioxane-2-ol (22347-47-3) + p-dioxanone (3041-16-5,29223-92-5)

Guidance literature:

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; nitromethane; oxygen; 1,10-ethyleneisoalloxazinium chloride; at 40 ℃; for 24h;

DOI:10.1021/acs.joc.0c01013

Reference yield: 60.0%

2-(2-methoxyethoxy)acetic acid (16024-56-9) → p-dioxanone (3041-16-5,29223-92-5)

Guidance literature:

With hydrogen bromide; In water; at 0 ℃; pH=3; Reflux;

DOI:10.1021/tx3000076

upstream raw materials:

2-acetoxy-3-chloro-[1,4]dioxane

trans-2,3-dichloro-1,4-dioxane

(2-chloroethoxy)-acetic acid

2-(2-methoxyethoxy)acetic acid

Downstream raw materials:

(2-chloro-ethoxy)-acetic acid ethyl ester

2-(2-hydroxyethoxymethyl)-1H-benzimidazole

2-(2-hydroxyethoxy)-acetamide

2-(2-hydroxy-ethoxy)-1,1-di-p-tolyl-ethanol

Refernces

• 1、 Summerbell,Lunk. "-". . p. 604. Retrieved 1958.
• 2、 -. "Method for preparing P-dioxanone from diethylene glycol and catalyst thereof". Paragraph 0047-0075. . Retrieved 2021/05/01.
• 3、 Tang, Yidan,Meador, Rowan I. L.,Malinchak, Casina T.,Harrison, Emily E.,McCaskey, Kimberly A.,Hempel, Melanie C.,Funk, Timothy W.. "(Cyclopentadienone)iron-Catalyzed Transfer Dehydrogenation of Symmetrical and Unsymmetrical Diols to Lactones". . p. 1823 - 1834. Retrieved 2020/02/04.