Technology Process of [(3S)-4-benzylmorpholin-3-yl]methanol hydrochloride
There total 2 articles about [(3S)-4-benzylmorpholin-3-yl]methanol hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(3R)-5-oxo-4-(phenylmethyl)-3-morpholinecarboxylic acid;
With
dimethylsulfide borane complex;
In
tetrahydrofuran;
at 35 - 40 ℃;
for 5h;
Industry scale;
With
sodium hydroxide;
In
water; ethyl acetate; acetone;
at 40 ℃;
Industry scale;
With
methanol; chloro-trimethyl-silane;
In
ethyl acetate;
at 5 - 15 ℃;
for 2.25h;
Industry scale;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium carbonate / water; tetrahydrofuran / 2 h / 0 - 4 °C / Industry scale
1.2: 4.83 h / 3 - 10 °C / pH 13 - 13.5 / Industry scale
1.3: 3 - 6 °C / pH < 2 / Industry scale
2.1: dimethylsulfide borane complex / tetrahydrofuran / 5 h / 35 - 40 °C / Industry scale
2.2: 40 °C / Industry scale
2.3: 2.25 h / 5 - 15 °C / Industry scale
With
dimethylsulfide borane complex; potassium carbonate;
In
tetrahydrofuran; water;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogen / 20% palladium(II) hydroxide on carbon / ethanol / 3 h / 20 - 30 °C / 2311.54 Torr / Industry scale
2.1: N-ethyl-N,N-diisopropylamine / ethanol / 0.17 h / 25 °C / Industry scale
2.2: 1 h / 25 °C / Industry scale
2.3: 0.83 h / 25 - 30 °C / Industry scale
With
hydrogen; N-ethyl-N,N-diisopropylamine;
20% palladium(II) hydroxide on carbon;
In
ethanol;