(S)-3-Hydroxymethylmorpholine hydrochloride

Base Information

• Chemical Name: (S)-3-Hydroxymethylmorpholine hydrochloride
• CAS No.: 218594-79-7
• Molecular Formula: C5H11NO2
• Molecular Weight: 153.609
• Hs Code.: 2934999090
• Mol file: 218594-79-7.mol

Synonyms:(3S)-Morpholin-3-ylmethanol;(S)-3-Hydroxymethylmorpholine;AC1LTT73;H30270;CID1514268;

Chemical Property of (S)-3-Hydroxymethylmorpholine hydrochloride

Chemical Property:

• Boiling Point: 218.3 °C at 760 mmHg
• Flash Point: 85.9 °C
• PSA: 41.49000
• Density: 1.045 g/cm³
• LogP: 0.09790
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99.3% ^*data from raw suppliers

(S)-Morpholin-3-ylmethanolhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-3-Hydroxymethylmorpholine hydrochloride

There total 4 articles about (S)-3-Hydroxymethylmorpholine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-3-(hydroxymethyl)morpholine-4-carboxylic acid tert-butyl ester (714971-28-5) → (3S)-morpholin-3-ylmethanol hydrochloride (218594-79-7)

Guidance literature:

With hydrogenchloride; In methanol; at 0 - 20 ℃;

Reference yield:

[(3S)-4-benzylmorpholin-3-yl]methanol hydrochloride (916483-67-5) → (3S)-morpholin-3-ylmethanol hydrochloride (218594-79-7)

Guidance literature:

With hydrogen; 20% palladium(II) hydroxide on carbon; In ethanol; at 20 - 30 ℃; for 3h; under 2311.54 Torr; Industry scale;

Reference yield:

(3R)-5-oxo-4-(phenylmethyl)-3-morpholinecarboxylic acid (106973-36-8) → (3S)-morpholin-3-ylmethanol hydrochloride (218594-79-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 5 h / 35 - 40 °C / Industry scale

1.2: 40 °C / Industry scale

1.3: 2.25 h / 5 - 15 °C / Industry scale

2.1: hydrogen / 20% palladium(II) hydroxide on carbon / ethanol / 3 h / 20 - 30 °C / 2311.54 Torr / Industry scale

With dimethylsulfide borane complex; hydrogen; 20% palladium(II) hydroxide on carbon; In tetrahydrofuran; ethanol;

upstream raw materials:

(3R)-5-oxo-4-(phenylmethyl)-3-morpholinecarboxylic acid

[(3S)-4-benzylmorpholin-3-yl]methanol hydrochloride

(S)-3-(hydroxymethyl)morpholine-4-carboxylic acid tert-butyl ester

Downstream raw materials:

[(R)-1-benzyloxymethyl-2-((S)-3-hydroxymethyl-morpholin-4-yl)-2-oxoethyl] carbamic acid tert-butyl ester

Refernces

• 1、 -. "ANHYDRATE FORMS OF A PYRIDINE DERIVATIVE". . . Retrieved 2011/04/14.