3,4-dimethoxybenzyl 2,2,3,3,3-pentafluoropropionimidate

Base Information

• Chemical Name: 3,4-dimethoxybenzyl 2,2,3,3,3-pentafluoropropionimidate
• CAS No.: 212051-23-5
• Molecular Formula: C₁₂H₁₂F₅NO₃
• Molecular Weight: 313.224
• Mol file: 212051-23-5.mol

Synonyms:3,4-dimethoxybenzyl 2,2,3,3,3-pentafluoropropionimidate

Chemical Property of 3,4-dimethoxybenzyl 2,2,3,3,3-pentafluoropropionimidate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-dimethoxybenzyl 2,2,3,3,3-pentafluoropropionimidate

There total 2 articles about 3,4-dimethoxybenzyl 2,2,3,3,3-pentafluoropropionimidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pentafluoropropionitrile (422-04-8) + (3,4-dimethoxyphenyl)methanol (93-03-8) → 3,4-dimethoxybenzyl 2,2,3,3,3-pentafluoropropionimidate (212051-23-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at -78 - 20 ℃; for 10.25h;

DOI:10.1016/S0040-4020(02)00304-6

Reference yield:

2,2,3,3,3-pentafluoropropionamide (354-76-7) + (3,4-dimethoxyphenyl)methanol (93-03-8) → 3,4-dimethoxybenzyl 2,2,3,3,3-pentafluoropropionimidate (212051-23-5)

Guidance literature:

With oxalyl dichloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; Yield given. Multistep reaction; 1.) CH2Cl2, -78 deg C, 30 min; 2.) CH2Cl2, -78 deg C, 15 min, then --> room temp., 10 h;

DOI:10.1016/S0040-4039(98)01121-6

Reference yield: 98.0%

methyl (R)-3-hydroxy-2-methylpropionate (72657-23-9,42998-03-8) + 3,4-dimethoxybenzyl 2,2,3,3,3-pentafluoropropionimidate (212051-23-5) → methyl 3-(3,4-dimethoxy-benzyloxy)-2-(R)-methyl-propionate (212051-39-3)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/S0040-4020(02)00304-6

upstream raw materials:

2,2,3,3,3-pentafluoropropionamide

(3,4-dimethoxyphenyl)methanol

pentafluoropropionitrile

Downstream raw materials:

methyl 3-(3,4-dimethoxy-benzyloxy)-2-(R)-methyl-propionate

Refernces

• 1、 Nakajima, Noriyuki,Saito, Miho,Ubukata, Makoto. "Activated dimethyl sulfoxide dehydration of amide and its application to one-pot preparation of benzyl-type perfluoroimidates". . p. 3561 - 3577. Retrieved 2007/10/03.