Technology Process of 1-(3-chlorophenyl)-2-fluoroethan-1-ol
There total 7 articles about 1-(3-chlorophenyl)-2-fluoroethan-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Lactobacillus brevis alcohol dehydrogenase; NADP; magnesium chloride;
In
isopropyl alcohol;
at 30 ℃;
for 24h;
pH=7.5;
Concentration;
enantioselective reaction;
Enzymatic reaction;
DOI:10.1021/jo400962c
- Guidance literature:
-
With
D-glucose;
In
aq. phosphate buffer;
at 30 ℃;
pH=6.5;
Overall yield = 52 percent; enantioselective reaction;
Microbiological reaction;
DOI:10.1021/acs.orglett.0c01825
- Guidance literature:
-
Multi-step reaction with 3 steps
1: N-Bromosuccinimide; toluene-4-sulfonic acid / acetonitrile / 24 h / 50 °C
2: potassium fluoride; zinc(II) fluoride / acetonitrile / 24 h / 100 °C
3: NADP; Lactobacillus brevis alcohol dehydrogenase; magnesium chloride / isopropyl alcohol / 24 h / 30 °C / pH 7.5 / Enzymatic reaction
With
potassium fluoride; N-Bromosuccinimide; zinc(II) fluoride; Lactobacillus brevis alcohol dehydrogenase; NADP; toluene-4-sulfonic acid; magnesium chloride;
In
isopropyl alcohol; acetonitrile;
DOI:10.1021/jo400962c
