1-(3-chlorophenyl)-2-fluoroethan-1-ol

Base Information

• Chemical Name: 1-(3-chlorophenyl)-2-fluoroethan-1-ol
• CAS No.: 1446417-90-8
• Molecular Formula: C₈H₈ClFO
• Molecular Weight: 174.602
• Mol file: 1446417-90-8.mol

Synonyms:1-(3-chlorophenyl)-2-fluoroethan-1-ol

Chemical Property of 1-(3-chlorophenyl)-2-fluoroethan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-(3-chlorophenyl)-2-fluoroethan-1-ol

There total 6 articles about 1-(3-chlorophenyl)-2-fluoroethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(3-chlorophenyl)-2-fluoroethanone (90221-70-8) → 1-(3-chlorophenyl)-2-fluoroethan-1-ol (1446417-90-8) + 1-(3-chlorophenyl)-2-fluoroethan-1-ol (1446417-96-4)

Guidance literature:

With D-glucose; In aq. phosphate buffer; at 30 ℃; pH=6.5; Overall yield = 52 percent; enantioselective reaction; Microbiological reaction;

DOI:10.1021/acs.orglett.0c01825

Reference yield:

1-(3-chlorophenyl)-2-fluoroethanone (90221-70-8) → 1-(3-chlorophenyl)-2-fluoroethan-1-ol (1446417-90-8)

Guidance literature:

With Rhodococcus ruber alcohol dehydrogenase A overexpressed in E_. coli; NADH; In isopropyl alcohol; at 30 ℃; for 24h; pH=7.5; enantioselective reaction; Enzymatic reaction;

DOI:10.1021/jo400962c

Reference yield:

3-(3-chloro-phenyl)-3-oxo-propionic acid ethyl ester (33167-21-4) → 1-(3-chlorophenyl)-2-fluoroethan-1-ol (1446417-90-8) + 1-(3-chlorophenyl)-2-fluoroethan-1-ol (1446417-96-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Selectfluor; Candida antarctica lipase B / aq. phosphate buffer / 12 h / 50 °C / pH 7.4 / Enzymatic reaction

2: D-glucose / aq. phosphate buffer / 30 °C / pH 6.5 / Microbiological reaction

With Candida antarctica lipase B; D-glucose; Selectfluor; In aq. phosphate buffer;

DOI:10.1021/acs.orglett.0c01825

upstream raw materials:

1-(3-chlorophenyl)-2-fluoroethanone

3'-Chloroacetophenone

2-bromo-1-(3-chloro-phenyl)-ethanone

3-(3-chloro-phenyl)-3-oxo-propionic acid ethyl ester

Refernces

• 1、 Borzeicka, Wioleta,Lavandera, Ivan,Gotor, Vicente. "Synthesis of enantiopure fluorohydrins using alcohol dehydrogenases at high substrate concentrations". . p. 7312 - 7317. Retrieved 2013/08/23.