4-bromo-3-sulfamoylbenzoic acid

Base Information

• Chemical Name: 4-bromo-3-sulfamoylbenzoic acid
• CAS No.: 73035-18-4
• Molecular Formula: C₈H₈BrNO₃S
• Molecular Weight: 278.126
• Mol file: 73035-18-4.mol

Synonyms:4-bromo-3-sulfamoylbenzoic acid

Chemical Property of 4-bromo-3-sulfamoylbenzoic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromo-3-sulfamoylbenzoic acid

There total 3 articles about 4-bromo-3-sulfamoylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.2%

para-bromoacetophenone (99-90-1) → 4-bromo-3-sulfamoylbenzoic acid (73035-18-4)

Guidance literature:

para-bromoacetophenone; With chlorosulfonic acid; at 120 - 140 ℃; for 8h;

With ammonium hydroxide; In tetrahydrofuran; at 0 - 50 ℃; for 0.5h;

DOI:10.1039/c6ob01555g

Reference yield:

3'-amino-4'-bromoacetophenone (37148-51-9) → 4-bromo-3-sulfamoylbenzoic acid (73035-18-4)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1248/cpb.30.4092

Reference yield:

→ 4-bromo-3-sulfamoylbenzoic acid (73035-18-4)

Guidance literature:

entspr. Chlorsulfonylderivat, NH3;

upstream raw materials:

3'-amino-4'-bromoacetophenone

para-bromoacetophenone

Downstream raw materials:

3-[1-Hydroxy-2-(1-methyl-3-phenyl-propylamino)-ethyl]-5-methoxy-benzenesulfonamide; hydrochloride

3-{2-[Benzyl-(1-methyl-3-phenyl-propyl)-amino]-acetyl}-5-methoxy-benzenesulfonamide

3-{2-[Benzyl-(1-methyl-3-phenyl-propyl)-amino]-1-hydroxy-ethyl}-5-methoxy-benzenesulfonamide

2-bromo-5-(1,2-epoxyethyl)benzenesulfonamide

Refernces

• 1、 Fujikura,Miigata,Hashimoto,Imai,Takenaka. "Studies on benzenesulfonamide derivatives with α- and β-adrenergic antagonistic and antihypertensive activities". . p. 4092 - 4101. Retrieved 2007/10/02.