(S)_P(-)-O-ethyl phenylphosphonothioic acid

Base Information

• Chemical Name: (S)_P(-)-O-ethyl phenylphosphonothioic acid
• CAS No.: 67964-17-4
• Molecular Formula: C₈H₁₁O₂PS
• Molecular Weight: 202.214
• Mol file: 67964-17-4.mol

Synonyms:(S)_P(-)-O-ethyl phenylphosphonothioic acid

Chemical Property of (S)_P(-)-O-ethyl phenylphosphonothioic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)_P(-)-O-ethyl phenylphosphonothioic acid

There total 6 articles about (S)_P(-)-O-ethyl phenylphosphonothioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

O-Ethyl hydrogen phenylphosphonothioate dicyclohexylammonium salt (6230-64-4,76003-54-8,76003-55-9,76003-56-0) → O-ethyl S-hydrogenphenylphosphorothioic acid (6230-93-9,67964-16-3,67964-17-4,70269-57-7)

Guidance literature:

With sodium hydroxide; for 0.75h;

DOI:10.1021/ic2016897

Reference yield: 95.0%

(S)-O-ethyl phenylphosphonothioic acid (R)-1-phenylethylamine salt → (S)P(-)-O-ethyl phenylphosphonothioic acid (67964-17-4)

Guidance literature:

With hydrogenchloride; In water;

Reference yield:

O-ethyl phenylphosphonothioic acid (6230-93-9) → (R)P(+)-O-ethyl phenylphosphonothioic acid (70269-57-7) + (S)P(-)-O-ethyl phenylphosphonothioic acid (67964-17-4)

Guidance literature:

O-ethyl phenylphosphonothioic acid; With (R)-1-phenyl-ethyl-amine; In diethyl ether; at 20 ℃; for 6h;

With hydrogenchloride; for 1h;

DOI:10.1021/ol0483145

upstream raw materials:

ethyl Phenylphosphinate

O-Ethyl hydrogen phenylphosphonothioate dicyclohexylammonium salt

O-ethyl phenylphosphonothioic acid

diethyl phenylphosphonothioate

Downstream raw materials:

C₁₀H₁₅O₂PS

C₁₀H₁₅O₂PS

S-methyl O-ethyl ohenylphosphonothioate

(S)-O-ethyl O-methyl phenylphosphonothioate

Refernces

• 1、 Kuo, Louis Y.,Glazier, Sara K.. "Stereochemical inversion of phosphonothioate methanolysis by La(III) and Zn(II): Mechanistic implications for the degradation of organophosphate neurotoxins". . p. 328 - 335. Retrieved 2012/03/12.
• 2、 -. "Optical resolution reagent and manufacturing method of optically active amines that uses it". Page/Page column 18-19. . Retrieved 2008/06/13.