N,N-dimethyl-3-thiophenecarbothioamide

Base Information

• Chemical Name: N,N-dimethyl-3-thiophenecarbothioamide
• CAS No.: 130021-87-3
• Molecular Formula: C₇H₉NS₂
• Molecular Weight: 171.287
• Mol file: 130021-87-3.mol

Synonyms:N,N-dimethyl-3-thiophenecarbothioamide

Chemical Property of N,N-dimethyl-3-thiophenecarbothioamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N,N-dimethyl-3-thiophenecarbothioamide

There total 6 articles about N,N-dimethyl-3-thiophenecarbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.2%

3-hydroxymethyl-thiophene (71637-34-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → N,N-dimethyl-3-thiophenecarbothioamide (130021-87-3)

Guidance literature:

With ethylenediaminetetraacetic acid; cesium chloride; sulfur; sodium hydroxide; at 60 ℃; for 10h; Inert atmosphere;

Reference yield: 80.0%

3-(chloromethyl)thiophene (2746-23-8) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → N,N-dimethyl-3-thiophenecarbothioamide (130021-87-3)

Guidance literature:

With sulfur; sodium hydroxide; at 100 ℃; for 8h; Schlenk technique;

DOI:10.1002/ejoc.202100588

Reference yield: 73.0%

N,N-dimethyl-3-thiophene carboxamide (59906-37-5) → N,N-dimethyl-3-thiophenecarbothioamide (130021-87-3)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; trichlorosilane; sulfur; In toluene; at 115 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.5b02742

upstream raw materials:

3-Bromothiophene

bis(dimethylthiocarbamoyl)sulfide

thiophen-3-yl-acetic acid

dimethyl amine

Refernces

• 1、 -. "Method for preparing aryl thioamide compound". Paragraph 0128-0130. . Retrieved 2021/03/31.
• 2、 Kumar, Saurabh,Vanjari, Rajeshwer,Guntreddi, Tirumaleswararao,Singh, Krishna Nand. "Sulfur promoted decarboxylative thioamidation of carboxylic acids using formamides as amine proxy". . p. 2012 - 2017. Retrieved 2016/04/05.