Technology Process of tert-butyl 2-((2R,4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2-phenyl-1,3-dioxan-4-yl)acetate
There total 5 articles about tert-butyl 2-((2R,4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2-phenyl-1,3-dioxan-4-yl)acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
Trimethylacetic acid;
In
tetrahydrofuran; n-heptane; toluene;
at 110 ℃;
for 26h;
enantioselective reaction;
Inert atmosphere;
DOI:10.1002/chem.201204609
- Guidance literature:
-
Multi-step reaction with 4 steps
1: manganese(IV) oxide / toluene / 14 h / Inert atmosphere; Reflux
2: potassium tert-butylate / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere
3: bis(dibenzylideneacetone)-palladium(0); 1,4-di(diphenylphosphino)-butane; Thiosalicylic acid / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere
4: Trimethylacetic acid / tetrahydrofuran; toluene; n-heptane / 26 h / 110 °C / Inert atmosphere
With
manganese(IV) oxide; potassium tert-butylate; Thiosalicylic acid; 1,4-di(diphenylphosphino)-butane; bis(dibenzylideneacetone)-palladium(0); Trimethylacetic acid;
In
tetrahydrofuran; n-heptane; toluene;
DOI:10.1002/chem.201204609
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: rochelle salt / water / 2.5 h / 20 °C / Inert atmosphere
1.2: 1 h / 0 - 20 °C / Inert atmosphere
2.1: manganese(IV) oxide / toluene / 14 h / Inert atmosphere; Reflux
3.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere
4.1: bis(dibenzylideneacetone)-palladium(0); 1,4-di(diphenylphosphino)-butane; Thiosalicylic acid / tetrahydrofuran / 12 h / 60 °C / Inert atmosphere
5.1: Trimethylacetic acid / tetrahydrofuran; toluene; n-heptane / 26 h / 110 °C / Inert atmosphere
With
manganese(IV) oxide; potassium tert-butylate; Thiosalicylic acid; rochelle salt; 1,4-di(diphenylphosphino)-butane; bis(dibenzylideneacetone)-palladium(0); Trimethylacetic acid;
In
tetrahydrofuran; n-heptane; water; toluene;
DOI:10.1002/chem.201204609