Homoveratrylamine hydrochloride

Base Information

• Chemical Name: Homoveratrylamine hydrochloride
• CAS No.: 635-85-8
• Molecular Formula: C10H15 N O2 . Cl H
• Molecular Weight: 217.696
• Hs Code.: 2922299090
• European Community (EC) Number: 636-318-7
• NSC Number: 141621
• UNII: TTV20379WY
• DSSTox Substance ID: DTXSID00212904
• Wikidata: Q27290360
• Mol file: 635-85-8.mol

Synonyms:635-85-8;Homoveratrylamine hydrochloride;3,4-Dimethoxyphenethylamine hydrochloride;Benzeneethanamine, 3,4-dimethoxy-, hydrochloride;NSC 141621;UNII-TTV20379WY;3,4-Dimethoxyphenylethylamine hydrochloride;TTV20379WY;Phenethylamine, 3,4-dimethoxy-, hydrochloride;2-(3,4-dimethoxyphenyl)ethanamine;hydrochloride;3,4-Dimethoxy-beta-phenylethylamine hydrochloride;2-(3,4-dimethoxyphenyl)ethan-1-amine hydrochloride;NSC-141621;3,4-Dimethoxyphenethylamine (hydrochloride);2-(3,4-dimethoxyphenyl)ethylamine hydrochloride;[2-(3,4-dimethoxyphenyl)ethyl]amine hydrochloride;DMPEA HYDROCHLORIDE;O(C)c1cc(CCN)ccc1OC;SCHEMBL3745006;DTXSID00212904;WLN: Z2R CO1 DO1 &GH;NSC141621;AKOS004910783;CCG-221248;O,O-DIMETHYLDOPAMINE HYDROCHLORIDE;Phenethylamine,4-dimethoxy-, hydrochloride;LS-103297;Benzeneethanamine,4-dimethoxy-, hydrochloride;FT-0682656;2-(3,4-dimethoxyphenyl) ethylamine hydrochloride;3,4-Dimethoxy-.beta.-phenylethylamine hydrochloride;Q27290360;.BETA.-(3,4-DIMETHOXYPHENYL)ETHYLAMINE HYDROCHLORIDE;BENZENEETHANAMINE, 3,4-DIMETHOXY-, HYDROCHLORIDE (1:1)

Chemical Property of Homoveratrylamine hydrochloride

Chemical Property:

• Vapor Pressure: 0.000251mmHg at 25°C
• Melting Point: 195-196℃ (ethanol )
• Boiling Point: 324.1 °C at 760 mmHg
• Flash Point: 132.8 °C
• PSA: 44.48000
• LogP: 2.70730
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 217.0869564
• Heavy Atom Count: 14
• Complexity: 141

Purity/Quality:

99%, ^*data from raw suppliers

2-(3,4-Dimethoxyphenyl)ethanamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)CCN)OC.Cl
• Description: 3,4-Dimethoxyphenethylamine (hydrochloride) (Item No. 14141) is an analytical reference standard that is structurally categorized as a phenethylamine. It inhibits the deamination of tyramine and tryptamine by rat brain monoamine oxidase. This product is intended for research and forensic applications.
• Uses: 2-(3,4-dimethoxyphenyl)ethanamine hydrochloride (cas# 635-85-8) is used as a catalyst for cyclocondensation reactions of dihydroisoquinoline with acylcycloalkenes.

Technology Process of Homoveratrylamine hydrochloride

There total 6 articles about Homoveratrylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,4-dimethoxyphenylacetonitrile (93-17-4) → homoveratrylamine hydrochloride (635-85-8)

Guidance literature:

With hydrogenchloride; hydrogen; In propan-1-ol; water; at 60 ℃; for 18h; under 375.038 Torr; Flow reactor;

DOI:10.1002/open.201600166

Reference yield: 88.0%

1,2-dimethoxy-4-(2-nitroethyl)benzene (70360-83-7) → homoveratrylamine hydrochloride (635-85-8)

Guidance literature:

With palladium 10% on activated carbon; In methanol; at 20 ℃; for 24h;

DOI:10.1039/c6cc03295h

Reference yield: 71.2%

2-(3,4-dimethoxyphenyl)-ethylamine (120-20-7) → homoveratrylamine hydrochloride (635-85-8)

Guidance literature:

With hydrogenchloride; In isopropyl alcohol; at 50 ℃; Solvent;

upstream raw materials:

3,4-dimethoxy-benzaldehyde

3,4-dimethoxynitrostyrene

1,2-dimethoxy-4-(2-nitroethyl)benzene

3,4-dimethoxyphenylacetonitrile

Downstream raw materials:

[2-(3,4-Dimethoxy-phenyl)-ethyl]-[1-(3-phenyl-prop-2-ynyl)-4,5-dihydro-1H-imidazol-2-yl]-amine; hydrochloride

N-(3,4-Dimethoxy-phenaethyl)-3-(3,4,5-trimethoxy-phenyl)-propionsaeureamid

N-(3,4-Dimethoxy-phenylaethyl)-3-(3,5-dimethoxy-4-benzyloxy-phenyl)-propionamid

N,N'-bis[2-(3,4-dimethoxyphenyl)ethyl]thiourea

Refernces

• 1、 Sarkar, Koushik,Das, Kuhali,Kundu, Abhishek,Adhikari, Debashis,Maji, Biplab. "Phosphine-Free Manganese Catalyst Enables Selective Transfer Hydrogenation of Nitriles to Primary and Secondary Amines Using Ammonia-Borane". . p. 2786 - 2794. Retrieved 2021/03/03.
• 2、 Saito, Yuki,Ishitani, Haruro,Ueno, Masaharu,Kobayashi, Shū. "Selective Hydrogenation of Nitriles to Primary Amines Catalyzed by a Polysilane/SiO2-Supported Palladium Catalyst under Continuous-Flow Conditions". . p. 211 - 215. Retrieved 2017/04/21.