Technology Process of (2S,6S)-1-benzyl-2-methyl-6-((E)-prop-1-enyl)piperidine
There total 5 articles about (2S,6S)-1-benzyl-2-methyl-6-((E)-prop-1-enyl)piperidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-(ethylsulfonyl)-1-phenyl-1H-tetrazole;
With
potassium hexamethylsilazane;
In
1,2-dimethoxyethane;
at -78 ℃;
for 0.333333h;
Inert atmosphere;
C14H19NO;
In
1,2-dimethoxyethane;
at -78 - 20 ℃;
for 18h;
Inert atmosphere;
DOI:10.1016/j.tetasy.2011.11.006
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: palladium 10% on activated carbon; hydrogen / ethanol / 12 h / 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 0 - 20 °C
3.1: hydrogenchloride; ethanol / 5 h / 20 °C
4.1: pyridine-SO3 complex; triethylamine / dichloromethane; dimethyl sulfoxide / 0 - 20 °C
5.1: potassium hexamethylsilazane / 1,2-dimethoxyethane / 0.33 h / -78 °C / Inert atmosphere
5.2: 18 h / -78 - 20 °C / Inert atmosphere
With
hydrogenchloride; pyridine-SO3 complex; ethanol; palladium 10% on activated carbon; hydrogen; potassium hexamethylsilazane; potassium carbonate; triethylamine;
In
1,2-dimethoxyethane; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
4.1: Parikh-Doering oxidation / 5.2: Julia Olefin synthesis;
DOI:10.1016/j.tetasy.2011.11.006
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: pyridine-SO3 complex; triethylamine / dichloromethane; dimethyl sulfoxide / 0 - 20 °C
2.1: potassium hexamethylsilazane / 1,2-dimethoxyethane / 0.33 h / -78 °C / Inert atmosphere
2.2: 18 h / -78 - 20 °C / Inert atmosphere
With
pyridine-SO3 complex; potassium hexamethylsilazane; triethylamine;
In
1,2-dimethoxyethane; dichloromethane; dimethyl sulfoxide;
1.1: Parikh-Doering oxidation / 2.2: Julia Olefin synthesis;
DOI:10.1016/j.tetasy.2011.11.006
