(+)-Methadone hydrochloride

Base Information Edit

Chemical Name:(+)-Methadone hydrochloride
CAS No.:15284-15-8
Molecular Formula:C21H27 N O . Cl H
Molecular Weight:345.912
Hs Code.:
UNII:1Q1YXA5GYG
ChEMBL ID:CHEMBL5095396
NCI Thesaurus Code:C186382
Mol file:15284-15-8.mol

Synonyms:Dextromethadone hydrochloride;(S)-Methadone Hydrochloride;d-Methadone hydrochloride;15284-15-8;1Q1YXA5GYG;ESMETHADONE HYDROCHLORIDE;REL-1017 HYDROCHLORIDE;Esmethadone hydrochloride [USAN];METHADONE HYDROCHLORIDE, (S)-;3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, hydrochloride, (S)-;(+)-Methadone hydrochloride;d-Amidone hydrochloride;d-Dolophine hydrochloride;(S)-Methadone Hydrochloride (1.0mg/ml in Methanol);3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, hydrochloride (1:1), (6S)-;3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, hydrochloride, (6S)- (9CI);3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, hydrochloride, (S)- (8CI);(S)-Methadone hydrochloride;S-methadone hydrochloride;UNII-1Q1YXA5GYG;SCHEMBL6055296;CHEMBL5095396;J-501701;(6S)-6-(dimethylamino)-4,4-diphenyl-3-heptanone hcl;3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, hydrochloride, (6S)-;(6S)-6-(DIMETHYLAMINO)-4,4-DIPHENYLHEPTAN-3-ONE, HYDROCHLORIDE (1:1);3-HEPTANONE, 6-(DIMETHYLAMINO)-4,4-DIPHENYL-, HYDROCHLORIDE (1:1), (6S)-

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of (+)-Methadone hydrochloride Edit

Chemical Property:

Vapor Pressure:1.51E-08mmHg at 25°C
Melting Point:239-242°C (dec.)
Boiling Point:451.3°C at 760 mmHg
Flash Point:226.7°C
PSA：20.31000
LogP:5.09400
Storage Temp.:Controlled Substance, -20?C Freezer
Solubility.:H2O: soluble
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:7
Exact Mass:345.1859422
Heavy Atom Count:24
Complexity:346

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:Xn
Statements: 22-36/37/38-42/43
Safety Statements: 22-26-36/37/39-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2.Cl
Isomeric SMILES:CCC(=O)C(C[C@H](C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2.Cl
Uses S(+)-METHADONE HYDROCHLORIDE is a component of pharmaceuticals used in the treatment of opioid dependence.

Technology Process of (+)-Methadone hydrochloride

There total 8 articles about (+)-Methadone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 7576-08-1
(S)-(+)-2,2-diphenyl-4-dimethylaminopentanenitrile

: 925-90-6
ethylmagnesium bromide

: 15284-15-8
(+)-Methadone hydrochloride

Guidance literature:: (S)-(+)-2,2-diphenyl-4-dimethylaminopentanenitrile; ethylmagnesium bromide; In diethyl ether; toluene; at 0 - 110 ℃; Inert atmosphere;

With hydrogenchloride; In water; toluene; at 0 - 75 ℃; for 3h;