Levomethadone hydrochloride

Base Information

• Chemical Name: Levomethadone hydrochloride
• CAS No.: 5967-73-7
• Molecular Formula: C21H27 N O . Cl H
• Molecular Weight: 345.912
• European Community (EC) Number: 227-756-6
• UNII: V57LC776C0
• DSSTox Substance ID: DTXSID30975070
• Wikidata: Q27291550
• Mol file: 5967-73-7.mol

Synonyms:Levomethadone hydrochloride;l-Methadone hydrochloride;l-Polamidon hydrochloride;l-Amidone hydrochloride;l-Dolophine hydrochloride;Methadone hydrochloride, L-;(-)-Methadone hydrochloride;Methadone hydrochloride l-form;Methadone HCl l-form;5967-73-7;EINECS 227-756-6;UNII-V57LC776C0;l-6-Dimethylamino-4,4-diphenyl-3-heptanone hydrochloride;(R)-Dimethyl(1-methyl-4-oxo-3,3-diphenylhexyl)ammonium chloride;V57LC776C0;1,1-Diphenyl-1-(2-dimethylaminopropyl)-2-butanone;levomethadone HCl;3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, hydrochloride, (R)-;3-HEPTANONE, 6-(DIMETHYLAMINO)-4,4-DIPHENYL-, HYDROCHLORIDE, (-)-;d-Amidone hydrochloride;d-Dolophine hydrochloride;C21H27NO.ClH;L-polamidon (TN);SCHEMBL396161;DTXSID30975070;(6R)-6-(dimethylamino)-4,4-diphenylheptan-3-one hydrochloride;METHADONE L-FORM HYDROCHLORIDE;D-(-)-METHADONE HYDROCHLORIDE;LS-74489;LEVOMETHADONE HYDROCHLORIDE [MART.];LEVOMETHADONE HYDROCHLORIDE [WHO-DD];METHADONE L-FORM HYDROCHLORIDE [MI];D08122;LEVOMETHADONE HYDROCHLORIDE [EP MONOGRAPH];Q27291550;(6R)-6-(dimethylamino)-4,4-diphenylheptan-3-one;hydrochloride;6-(Dimethylamino)-4,4-diphenylheptan-3-one--hydrogen chloride (1/1);3-HEPTANONE, 6-(DIMETHYLAMINO)-4,4-DIPHENYL-, HYDROCHLORIDE (1:1), (6R)-

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Chemical Property of Levomethadone hydrochloride

Chemical Property:

• Vapor Pressure: 2.2E-07mmHg at 25°C
• Melting Point: 220-227°C
• Boiling Point: 423.7°C at 760 mmHg
• Flash Point: 126.5°C
• PSA: 20.31000
• LogP: 5.09400
• Storage Temp.: Controlled Substance, -20?C Freezer
• Solubility.: Soluble in water, freely soluble in ethanol (96 per cent).
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 7
• Exact Mass: 345.1859422
• Heavy Atom Count: 24
• Complexity: 346

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2.Cl
• Isomeric SMILES: CCC(=O)C(C[C@@H](C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2.Cl
• Recent ClinicalTrials: Study of LYN-014 in Individuals With Opioid Use Disorder Who Are Stable on Methadone Therapy
• Recent EU Clinical Trials: Treatment satisfaction and self-reported symptoms in patients under opioid maintenance therapy
• Uses: (R)-dimethyl(1-methyl-4-oxo-3,3-diphenylhexyl)ammonium chloride can be used as a component of pharmaceuticals used in the treatment of opioid dependence.

Technology Process of Levomethadone hydrochloride

There total 7 articles about Levomethadone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

levomethadone (125-58-6,297-88-1) → (R)-methadone hydrochloride (5967-73-7)

Guidance literature:

With hydrogenchloride; In methanol; at 25 - 30 ℃; for 1h; pH=1 - 1.5;

Reference yield: 92.0%

(R)-(-)-2,2-diphenyl-4-dimethylaminopentanenitrile (7576-16-1) + ethylmagnesium bromide (925-90-6) → (R)-methadone hydrochloride (5967-73-7)

Guidance literature:

(R)-(-)-2,2-diphenyl-4-dimethylaminopentanenitrile; ethylmagnesium bromide; In diethyl ether; toluene; at 0 - 110 ℃; Inert atmosphere;

With hydrogenchloride; In water; toluene; at 0 - 70 ℃; for 3h; Temperature;

Reference yield: 91.0%

ethylmagnesium bromide (925-90-6) + levomethadone nitrile hydrochloride (78208-11-4) → (R)-methadone hydrochloride (5967-73-7)

Guidance literature:

ethylmagnesium bromide; levomethadone nitrile hydrochloride; In tetrahydrofuran; toluene; at -15 - 110 ℃; for 5.25h; Inert atmosphere;

With hydrogenchloride; In water; at 20 ℃; for 0.25h;

upstream raw materials:

(R)-(-)-2,2-diphenyl-4-dimethylaminopentanenitrile

ethylmagnesium bromide

Diphenylacetonitrile

methadone hydrochloride

Downstream raw materials:

Methadone

Refernces

• 1、 -. "SYNTHESIS OF LEVOMETHADONE HYDROCHLORIDE OR DEXTROMETHADONE HYDROCHLORIDE AND METHODS FOR USE THEREOF". Paragraph 00345-00347. . Retrieved 2017/03/14.
• 2、 -. "Methadone chiral isolate as an improved pharmaceutical". Page/Page column 1. . Retrieved 2010/02/17.