levomethadone nitrile hydrochloride

Base Information

• Chemical Name: levomethadone nitrile hydrochloride
• CAS No.: 78208-11-4
• Molecular Formula: C₁₉H₂₂N₂*ClH
• Molecular Weight: 314.858
• Mol file: 78208-11-4.mol

Synonyms:levomethadone nitrile hydrochloride

Chemical Property of levomethadone nitrile hydrochloride

Chemical Property:

Purity/Quality:

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Technology Process of levomethadone nitrile hydrochloride

There total 1 articles about levomethadone nitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

Diphenylacetonitrile (86-29-3) + (R)-1-chloro-N,N-dimethylpropane-2-amine hydrochloride → levomethadone nitrile hydrochloride (78208-11-4)

Guidance literature:

Diphenylacetonitrile; (R)-1-chloro-N,N-dimethylpropane-2-amine hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h; Inert atmosphere;

With potassium tert-butylate; In N,N-dimethyl-formamide; at 0 - 58 ℃; for 14.75h;

Reference yield: 91.0%

ethylmagnesium bromide (925-90-6) + levomethadone nitrile hydrochloride (78208-11-4) → (R)-methadone hydrochloride (5967-73-7)

Guidance literature:

ethylmagnesium bromide; levomethadone nitrile hydrochloride; In tetrahydrofuran; toluene; at -15 - 110 ℃; for 5.25h; Inert atmosphere;

With hydrogenchloride; In water; at 20 ℃; for 0.25h;

upstream raw materials:

Diphenylacetonitrile

Downstream raw materials:

(R)-methadone hydrochloride

Refernces