S-Methyl-S-(2-pyridinyl) sulfoximine

Base Information

• Chemical Name: S-Methyl-S-(2-pyridinyl) sulfoximine
• CAS No.: 76456-06-9
• Molecular Formula: C₆H₈N₂OS
• Molecular Weight: 156.208
• Hs Code.: 29350090
• European Community (EC) Number: 847-403-5
• Nikkaji Number: J2.507.500E
• Mol file: 76456-06-9.mol

Synonyms:S-Methyl-S-(2-pyridinyl) sulfoximine;76456-06-9;imino-methyl-oxo-pyridin-2-yl-lambda6-sulfane;imino(methyl)(pyridin-2-yl)-lambda6-sulfanone;S-methyl-S-pyridyl-sulfoximine;SCHEMBL15695399;BDA45606;MFCD09878530;S-Methyl-S-(2-pyridinyl)sulfoximine;AKOS006312037;AS-79533;S- Methyl- S- 2- pyridinyl-sulfoximine;imino(methyl)(pyridin-2-yl)-l6-sulfanone;imino(methyl)(pyridin-2-yl)-lambda-sulfanone;EN300-307839;F88134

Chemical Property of S-Methyl-S-(2-pyridinyl) sulfoximine

Chemical Property:

• Melting Point: 61-63 °C
• Boiling Point: 266.3±32.0 °C(Predicted)
• Density: 1.25
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 156.03573406
• Heavy Atom Count: 10
• Complexity: 208

Purity/Quality:

99% ^*data from raw suppliers

S-Methyl-S-(2-pyridinyl)sulfoximine 90% ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22-36/37/38
• Safety Statements: 22-26-7/8-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CS(=N)(=O)C1=CC=CC=N1

Technology Process of S-Methyl-S-(2-pyridinyl) sulfoximine

There total 16 articles about S-Methyl-S-(2-pyridinyl) sulfoximine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-[1-(acetoxymethyl)cyclohexanecarboxyl]-S-methyl-S-2-pyridylsulfoximine (1384980-71-5) → 1-(hydroxymethyl)cyclohexane-1-carboxylic acid (55987-28-5) + imino(methyl)(pyridin-2-yl)-λ6-sulfanone (76456-06-9)

Guidance literature:

With hydrogenchloride; water; at 50 ℃; for 5h;

DOI:10.1021/ol301579q

Reference yield: 90.0%

N-[3-acetoxy-2-benzyl-2-methylpropanoyl]-S-methyl-S-2-pyridylsulfoximine (1384980-70-4) → 2-hydroxymethyl-2-methyl-3-phenylpropanoic acid (594837-44-2) + imino(methyl)(pyridin-2-yl)-λ6-sulfanone (76456-06-9)

Guidance literature:

With hydrogenchloride; water; at 50 ℃; for 6h;

DOI:10.1021/ol301579q

Reference yield: 90.0%

2-methylsulfanyl-pyridine (18438-38-5,79639-75-1) → imino(methyl)(pyridin-2-yl)-λ6-sulfanone (76456-06-9)

Guidance literature:

With ammonium hydroxide; [bis(acetoxy)iodo]benzene; In methanol; at 0 ℃; for 0.25h; Flow reactor; Green chemistry;

DOI:10.1002/ejoc.201700850

upstream raw materials:

methyl 2-pyridyl sulfimide

N-(trifluoroacetyl)-S-methyl-S-(2-pyridyl)sulfoximine

N-(4-nitrobenzenesulfonyl) methyl (2-pyridinyl) sulfoximine

2-methylsulfanyl-pyridine

Downstream raw materials:

N-[3-acetoxy-2-(4-methoxybenzyl)-2-methylpropanoyl]-S-methyl-S-2-pyridylsulfoximine

N-[2,2-dimethyl-3-(4-methoxyphenyl)propanoyl]-S-methyl-S-2-pyridylsulfoximine

N-[2,2-dimethyl-3-(4-bromophenyl)propanoyl]-S-methyl-S-2-pyridylsulfoximine

N-[3-acetoxy-2,2-dibenzylpropanoyl]-S-methyl-S-2-pyridylsulfoximine

Refernces

• 1、 Chen, Hongyi,Chen, Li,He, Ze,Zeng, Qingle. "Blue light-promoted radical sulfoximido-chalcogenization of aliphatic and aromatic alkenes". supporting information. p. 2624 - 2627. Retrieved 2021/04/21.
• 2、 Han, Xu,Li, Chunpu,Li, Jian,Liu, Hong,Wang, Bao. "Sulfoximines-assisted Rh(III)-catalyzed C-H activation and intramolecular annulation for the synthesis of fused isochromeno-1,2-benzothiazines scaffolds under room temperature". . . Retrieved 2020/06/29.