ROLITETRACYCLINE

Base Information

• Chemical Name: ROLITETRACYCLINE
• CAS No.: 751-97-3
• Molecular Formula: C27H33 N3 O8
• Molecular Weight: 527.574
• Mol file: 751-97-3.mol

Synonyms:2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmethyl)-(6CI,8CI); 2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmethyl)-,[4S-(4a,4aa,5aa,6b,12aa)]-;4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmethyl)-2-naphthacenecarboxamide;Abricycline; Bristacin; N-(1-Pyrrolidinylmethyl)tetracycline;N-(Pyrrolidinomethyl)tetracycline; Pyrrolidinylmethyltetracycline; Reverin;Rolitetracycline; SQ 15659; Superciclin; Synotodecin; Syntetrin; Tetraverin;Transcycline; Velacycline

Chemical Property of ROLITETRACYCLINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 163.5°C
• Refractive Index: 1.7120 (estimate)
• Boiling Point: 824.37°C at 760 mmHg
• PKA: pKa 7.4 (Uncertain)
• Flash Point: 452.363°C
• PSA: 170.87000
• Density: 1.542g/cm³
• LogP: 0.79860
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Very Slightly)
• Water Solubility.: >20g/L(21 oC)

Purity/Quality:

98%Min ^*data from raw suppliers

Rolitetracycline(TechnicalGrade) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Rolitetracycline is a tetracycline antibiotic that may be given intravenously or intramuscularly in serious bacterial infections when oral administration is not practicable. Rolitetracycline, launched in the late 1950s, was the first of the semi-synthetic tetracyclines. Rolitetracycline is formed by a Mannich condensation of formaldehyde and pyrrolidine with tetracycline. Rolitetracycline is a pro-drug of tetracycline, in which the pyrrolidine moiety improves bioavailability compared with tetracycline. Rolitetracycline has broad spectrum Gram positive activity in vivo, but pH instability limits use to parenteral administration. The intrinsic in vitro activity and SARs for this region of the tetracycline molecule have not been extensively investigated.

Technology Process of ROLITETRACYCLINE

There total 2 articles about ROLITETRACYCLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

pyrrolidine (123-75-1) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → rolitetracycline (751-97-3)

Guidance literature:

(Edukt 1: (4aS)-4c-Dimethylamino-3,6t,10,12,12a-pentahydroxy-6c-methyl-1,11-dioxo-(4ar,5ac,12ac)-1,4,4a,5,5a,6,11,12a-octahydro-naphthacen-2-carbonsaeure-amid);

Reference yield:

→ 4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmethyl)-1,4,4a,5,5a,6,11,12a-octahydro-2-naphthacenecarboxamide (751-97-3,43181-07-3)

Guidance literature:

Tetracyclin, wss. Formaldehyd, Pyrrolidin, sd. A.;

upstream raw materials:

pyrrolidine

formaldehyd