CAS No.751-97-3,ROLITETRACYCLINE Suppliers

Products Categories

Pharmaceutical (11)
Organic Chemicals (4)
Others (1)
Plant Extract (1)

Basic Information

Molecular Structure:
CAS No.:	751-97-3
Name:	ROLITETRACYCLINE

Formula:	C27H33 N3 O8
Molecular Weight:	527.574
Synonyms:	2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmethyl)-(6CI,8CI); 2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmethyl)-,[4S-(4a,4aa,5aa,6b,12aa)]-;4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmethyl)-2-naphthacenecarboxamide;Abricycline; Bristacin; N-(1-Pyrrolidinylmethyl)tetracycline;N-(Pyrrolidinomethyl)tetracycline; Pyrrolidinylmethyltetracycline; Reverin;Rolitetracycline; SQ 15659; Superciclin; Synotodecin; Syntetrin; Tetraverin;Transcycline; Velacycline
Density:	1.542g/cm³
Melting Point:	163.5°C
Boiling Point:	824.37°C at 760 mmHg
Flash Point:	452.363°C
Solubility:	>20g/L(21 oC)
Hazard Symbols:	Xn
Risk Codes:	22-36/37/38
Safety:	Poison by intravenous route. Experimental teratogenic effects. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.
PSA:	170.87000
LogP:	0.79860

Synthetic route

: 123-75-1
pyrrolidine

: 50-00-0
formaldehyd

tetracycline: tetracycline

: 751-97-3
rolitetracycline

Conditions

Conditions	Yield
(Edukt 1: (4aS)-4c-Dimethylamino-3,6t,10,12,12a-pentahydroxy-6c-methyl-1,11-dioxo-(4ar,5ac,12ac)-1,4,4a,5,5a,6,11,12a-octahydro-naphthacen-2-carbonsaeure-amid);

...Expand

Country:
Business Type:
All

Lab/Research institutions

Trading Company

Manufacturers

Other
Certificate:
Manufacturer

Enterprise Authentication

ISO

GMP

FDA

HALAL

Display:default sort
Suppiers of more reward points first

New supplier

Total:17 Page 1 of 1 1

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 751-97-3

Chemistry

Product Name: Rolitetracycline (CAS NO.751-97-3)

Molecular Formula: C₂₇H₃₃N₃O₈
Molecular Weight: 527.57g/mol
Mol File: 751-97-3.mol
Einecs: 212-031-9
Boiling point: 735.9 °C at 760 mmHg
Flash Point: 398.9 °C
Density: 1.54 g/cm³
Surface Tension: 89.2 dyne/cm
Enthalpy of Vaporization: 112.7 kJ/mol
Vapour Pressure: 9.72E-23 mmHg at 25°C
XLogP3-AA: 0
H-Bond Donor: 6
H-Bond Acceptor: 11
Structure Descriptors of Rolitetracycline (CAS NO.751-97-3):
IUPAC Name: (2Z,4S,4aS,6S,12aS)-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-2-[hydroxy-(pyrrolidin-1-ylmethylamino)methylidene]-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione
Canonical SMILES: CC1(C2CC3C(C(=O)C(=C(NCN4CCCC4)O)C(=O)C3(C(=O)C2=C(C5=C1C=CC=C5O)O)O)N(C)C)O
Isomeric SMILES: C[C@@]1(C2C[C@H]3[C@@H](C(=O)/C(=C(\NCN4CCCC4)/O)/C(=O)[C@]3(C(=O)C2=C(C5=C1C=CC=C5O)O)O)N(C)C)O
InChI: InChI=1S/C27H33N3O8/c1-26(37)13-7-6-8-16(31)17(13)21(32)18-14(26)11-15-20(29(2)3)22(33)19(24(35)27(15,38)23(18)34)25(36)28-12-30-9-4-5-10-30/h6-8,14-15,20,28,31-32,36-38H,4-5,9-12H2,1-3H3/b25-19-/t14?,15-,20-,26+,27-/m0/s1
InChIKey: YHDPWEWZPGTMMU-DLPVWNROSA-N

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
dog	LD50	intravenous	93mg/kg (93mg/kg)	Drugs in Japan Vol. 6, Pg. 914, 1982.
mouse	LD50	intraperitoneal	225mg/kg (225mg/kg)	United States Patent Document. Vol. #3846486,
mouse	LD50	intravenous	75mg/kg (75mg/kg)	Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 63, 1959.
mouse	LD50	oral	1320mg/kg (1320mg/kg)	Journal of Pharmacy and Pharmacology. Vol. 16, Pg. 33, 1964.
rabbit	LD50	intravenous	47mg/kg (47mg/kg)	Drugs in Japan Vol. 6, Pg. 914, 1982.

Safety Profile

Poison by intravenous route. Experimental teratogenic effects. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x.
Safety Information of Rolitetracycline (CAS NO.751-97-3):
Hazard Codes: Xn Harmful
Risk Statements: 22-36/37/38
22: Harmful if swallowed
36: Irritating to the eyes
37: Irritating to the respiratory system
38: Irritating to the skin
Safety Statements: 26-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing

Specification

Rolitetracycline ,its CAS NO. is 751-97-3,the synonyms is 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmethyl)-, (4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha))- ; 4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-N-(1-pyrrolidinylmethyl)-2-naphthacenecarboxamide ; Bristacin ; EINECS 212-031-9 ; N-(1-Pyrrolidinylmethyl)-tetracycline ; N-(Pyrrolidinomethyl)tetracycline ; Pirrolidinometil-tetraciclina ; Prm-TC ; Pyrrolidino-methyl-tetracycline ; Reverin ; Rolitetraciclina ; Rolitetracyclinum ; SQ 15,659 ; Superciclin ; Synotodecin ; Syntetrex ; Syntetrin ; Tetracycline, pyrrolidinomethyl- ; Transcycline ; UNII-GH9IW85221 ; Velacicline ; Velacycline ; n-Pyrrolidino-methyl-tetracycline .