Levobunolol

Base Information

• Chemical Name: Levobunolol
• CAS No.: 47141-42-4
• Molecular Formula: C₁₇H₂₅NO₃
• Molecular Weight: 291.39
• Hs Code.: DERIVATION
• UNII: G6317AOI7K
• DSSTox Substance ID: DTXSID1043833
• Nikkaji Number: J237.992I
• Wikipedia: Levobunolol
• Wikidata: Q408556
• NCI Thesaurus Code: C62043
• RXCUI: 1813
• Pharos Ligand ID: B2DL3ZCUUTWL
• Metabolomics Workbench ID: 43424
• ChEMBL ID: CHEMBL1201237
• Mol file: 47141-42-4.mol

Synonyms:AKBeta;Apo Levobunolol;Apo-Levobunolol;ApoLevobunolol;Betagan;Levobunolol;Levobunolol Hydrochloride;Novo Levobunolol;Novo-Levobunolol;NovoLevobunolol;PMS Levobunolol;PMS-Levobunolol;PMSLevobunolol;ratio Levobunolol;ratio-Levobunolol;Ultracortenol;Vistagan;W 7000A;W-7000A;W7000A

Chemical Property of Levobunolol

Chemical Property:

• Appearance/Colour: white to pink powder
• Melting Point: 205 - 210 C
• PSA: 58.56000
• LogP: 2.72430
• Storage Temp.: -20?C Freezer, Under Inert Atmosphere
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 291.18344366
• Heavy Atom Count: 21
• Complexity: 350

Purity/Quality:

98% ^*data from raw suppliers

LevobunololHCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s): UN NO.
• Hazard Codes: UN NO.

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)NCC(COC1=CC=CC2=C1CCCC2=O)O
• Isomeric SMILES: CC(C)(C)NC[C@@H](COC1=CC=CC2=C1CCCC2=O)O
• Uses: Levobunolol hydrochloride is an antiglaucoma agent in ophthalmie solutions. As a non-selective adrenoceptor antagonist, Levobunolol is used as an anticonvulsant.
• Therapeutic Function: Beta-adrenergic blocker

Technology Process of Levobunolol

There total 5 articles about Levobunolol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Hydroxy-1-tetralone (28315-93-7) + tert-butylamine (75-64-9) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → bunolol (27591-01-1,47141-42-4)

Guidance literature:

Multistep reaction; (i) aq. NaOH, EtOH, (ii) /BRN= 605267/;

DOI:10.1021/jm00298a024

Reference yield:

→ bunolol (27591-01-1,47141-42-4)

Guidance literature:

Reference yield:

5-Hydroxy-1-tetralone (28315-93-7) + tert-butylamine (75-64-9) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → d-bunolol (47141-42-4)

Guidance literature:

Multistep reaction; (i) aq. NaOH, EtOH, (ii) /BRN= 605267/, (iii) (racemate resolution using (+)(S)-tartaric acid);

DOI:10.1021/jm00298a024

upstream raw materials:

5-Hydroxy-1-tetralone

tert-butylamine

epichlorohydrin

Refernces

• 1、 -. "THERAPY FOR COMPLICATIONS OF DIABETES". . . Retrieved 2009/07/02.
• 2、 -. "Method for treating resistant hypertension". . . Retrieved 2008/06/13.