2-(12-Fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH,8H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl)-2-oxoethyl acetate

Base Information Edit

Chemical Name:2-(12-Fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH,8H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl)-2-oxoethyl acetate
CAS No.:4533-89-5
Molecular Formula:C26H33 F O7
Molecular Weight:476.542
Hs Code.:
European Community (EC) Number:224-871-3
DSSTox Substance ID:DTXSID40963367
Mol file:4533-89-5.mol

2-(12-Fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH,8H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl)-2-oxoethyl acetate

Synonyms:DTXSID40963367;4533-89-5;2-(12-Fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH,8H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl)-2-oxoethyl acetate

Suppliers and Price of 2-(12-Fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH,8H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl)-2-oxoethyl acetate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
FlunisolideAcetate
1mg
$ 85.00

American Custom Chemicals Corporation
FLUNISOLIDE ACETATE 95.00%
5MG
$ 495.08

Total 2 raw suppliers

Chemical Property of 2-(12-Fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH,8H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl)-2-oxoethyl acetate Edit

Chemical Property:

Vapor Pressure:1.4E-16mmHg at 25°C
Boiling Point:581.8°Cat760mmHg
Flash Point:305.7°C
PSA：99.13000
Density:1.33g/cm³
LogP:2.84550
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:476.22103155
Heavy Atom Count:34
Complexity:1020

Purity/Quality:

99% ^*data from raw suppliers

FlunisolideAcetate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)OCC(=O)C12C(CC3C1(CC(C4C3CC(C5=CC(=O)C=CC45C)F)O)C)OC(O2)(C)C
Isomeric SMILES:CC(=O)OCC(=O)[C@@]12[C@@H](CC3C1(CC([C@H]4C3C[C@@H](C5=CC(=O)C=CC45C)F)O)C)OC(O2)(C)C
Uses Flunisolide Acetate is a synthetic fluorinated corticosteroid related to Prednisolone (P703740). Antiasthmatic.

Technology Process of 2-(12-Fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH,8H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl)-2-oxoethyl acetate

There total 16 articles about 2-(12-Fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH,8H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl)-2-oxoethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4991-55-3
6α-fluoro-9α-bromo-11β-hydroxy-16α-17α-isopropylidenedioxy-21-acetoxypregna-1,4-diene-3,20-dione

: 4533-89-5
21-(acetyloxy)-6α-fluoro-11β-hydroxy-16α,17-<(1-methylethylidene)bis(oxy)>pregna-1,4-diene-3,20-dione

Guidance literature:: With chromium(III) chloride hexahydrate; mercaptoacetic acid; zinc; In dimethyl sulfoxide; N,N-dimethyl-formamide; at -10 - -7 ℃; for 2h; Inert atmosphere;

Reference yield:

: 108-22-5
Isopropenyl acetate

: 638-94-8
desonide

: 4533-89-5
21-(acetyloxy)-6α-fluoro-11β-hydroxy-16α,17-<(1-methylethylidene)bis(oxy)>pregna-1,4-diene-3,20-dione

Guidance literature:: Isopropenyl acetate; desonide; With methanesulfonic acid; at 65 - 80 ℃; for 1h;

With Selectfluor; In water; acetonitrile; at -5 - 15 ℃; for 12h;