Piroximone

Base Information

• Chemical Name: Piroximone
• CAS No.: 84490-12-0
• Molecular Formula: C11H11N3O2
• Molecular Weight: 217.227
• Hs Code.: 2933990090
• Mol file: 84490-12-0.mol

Synonyms:Piroximonum;1,3-dihydro-4-ethyl-5-isonicotinoyl-2H-imidazole-2-one;Piroximona;MDL 19,205;1,3-dihydro-4-isonicotinoyl-5-ethyl-2H-imidazol-2-one;Piroximone;

Chemical Property of Piroximone

Chemical Property:

• PSA: 78.61000
• Density: 1.245g/cm³
• LogP: 0.89140

Purity/Quality:

Morethan98% ^*data from raw suppliers

PIROXIMONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Cardiotonic.

Technology Process of Piroximone

There total 3 articles about Piroximone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ piroximone (84490-12-0)

Guidance literature:

Reference yield:

potassium pyridine-4-carboxylate (25108-37-6) → piroximone (84490-12-0)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride / CH₂Cl₂ / 0.5 h / Heating

2: aluminum chloride / 1.) CH₂Cl₂, 2.) 120 deg C, 30 min

With aluminium trichloride; oxalyl dichloride; In dichloromethane;

DOI:10.1021/jm00155a043

Reference yield:

4-(chlorocarbonyl)pyridine (14254-57-0) + 1,2-dihydro-4-ethyl-2H-imidazol-2-one (83962-06-5) → piroximone (84490-12-0)

Guidance literature:

With aluminium trichloride; Yield given; 1.) CH₂Cl₂, 2.) 120 deg C, 30 min;

DOI:10.1021/jm00155a043

upstream raw materials:

4-(chlorocarbonyl)pyridine

1,2-dihydro-4-ethyl-2H-imidazol-2-one

potassium pyridine-4-carboxylate

Downstream raw materials:

pyridine-4-carboxylic acid

Refernces

• 1、 Schnettler, Richard A.,Dage, Richard C.,Palopoli, Frank P.. "4-Aroyl-1,3-dihydro-2H-imidazol-2-ones: A New Class of Cardiotonic Agents. 2. Effect of 4-Pyridoyl Substituents and Related Compounds". . p. 860 - 862. Retrieved 2007/10/02.