1-Formyl-2-phenylhydrazine

Base Information

• Chemical Name: 1-Formyl-2-phenylhydrazine
• CAS No.: 622-84-4
• Molecular Formula: C7H8N2O
• Molecular Weight: 136.153
• NSC Number: 406126,122444
• UNII: VE4U62H7IL
• DSSTox Substance ID: DTXSID50211245
• Nikkaji Number: J36.946B
• Wikidata: Q72479392
• Mol file: 622-84-4.mol

Synonyms:1-Formyl-2-phenylhydrazine;622-84-4;N'-phenylformohydrazide;N-anilinoformamide;Hydrazinecarboxaldehyde, 2-phenyl-;Formic acid, 2-phenylhydrazide;N'-Formyl-N-phenylhydrazine;HYDRAZINE, 1-FORMYL-2-PHENYL-;N-Formylfenylhydrazin;2-Formyl-1-phenylhydrazine;Fenylhydrazid kyseliny mravenci;N-Formylfenylhydrazin [Czech];NSC 122444;NSC 406126;N'-phenylcarbohydrazide;N'-Phenylformic hydrazide;1-Phenyl-2-formylhydrazine;Fenylhydrazid kyseliny mravenci [Czech];BRN 0956804;VE4U62H7IL;AI3-01558;NSC-122444;NSC-406126;WLN: VHMMR;3-15-00-00154 (Beilstein Handbook Reference);2-Phenylhydrazine-1-carboxaldehyde;2-Phenylhydrazinecarboxaldehyde;N'-Phenylformhydrazide;Ameisensaure-phenylhydrazid;UNII-VE4U62H7IL;NCIOpen2_003649;N'-Phenylformic hydrazide #;SCHEMBL243768;DTXSID50211245;BCP27079;MFCD00043517;NSC122444;NSC406126;(.BETA.-FORMYLPHENYL)HYDRAZINE;AKOS004907806;SB86019;LS-76804;CS-0243439;FT-0607790;A15707;EN300-263667;Z1198148433

Chemical Property of 1-Formyl-2-phenylhydrazine

Chemical Property:

• Vapor Pressure: 0.0811mmHg at 25°C
• Melting Point: 142-143ºC
• Refractive Index: 1.605
• Boiling Point: 226.6 °C at 760 mmHg
• PKA: 12.94±0.23(Predicted)
• Flash Point: 103.1 °C
• PSA: 41.13000
• Density: 1.183 g/cm³
• LogP: 1.85930
• Storage Temp.: 2-8°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 136.063662883
• Heavy Atom Count: 10
• Complexity: 99.8

Purity/Quality:

99%, ^*data from raw suppliers

N-Anilinoformamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)NNC=O

Technology Process of 1-Formyl-2-phenylhydrazine

There total 50 articles about 1-Formyl-2-phenylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-cycloheptylidene-2-phenylhydrazine (3349-69-7) → 2-formyl-1-phenylhydrazine (622-84-4) + cycloheptanone (502-42-1)

Guidance literature:

With formic acid; In ethanol; for 5h; Heating;

DOI:10.1080/00397919808006833

Reference yield: 92.0%

formic acid (64-18-6) + phenylhydrazine (100-63-0) → 2-formyl-1-phenylhydrazine (622-84-4)

Guidance literature:

With (1-methyl-3-(3-sulfopropyl)-1H-imidazol-3-ium)₃[PW₁₂O₄₀^3-]; In neat (no solvent); at 70 ℃; for 0.5h; Green chemistry;

DOI:10.1016/j.tet.2014.02.042

Reference yield: 87.0%

formic acid (64-18-6) + 1-cycloheptylidene-2-phenylhydrazine (3349-69-7) → 2-formyl-1-phenylhydrazine (622-84-4) + cycloheptanone (502-42-1)

Guidance literature:

In ethanol; for 5h; Heating;

DOI:10.1080/00397919808006833

upstream raw materials:

2-methyl-pent-2-enal-phenylhydrazone

5-Acetyl-1,5-diphenyl-formazan

formamide

acetic acid

Downstream raw materials:

1-phenyl-1H-1,2,4-triazole

Formic acid N'-(3-oxo-butyl)-N'-phenyl-hydrazide

1-phenyl-1H-1,2,4-triazol-5-one

2-Cyano-3-(4-{N'-[1-phenyl-eth-(E)-ylidene]-hydrazino}-phenyl)-but-2-enedinitrile

Refernces

• 1、 Lv, Hui,Xing, Qi,Yue, Chengtao,Lei, Ziqiang,Li, Fuwei. "Solvent-promoted catalyst-free: N -formylation of amines using carbon dioxide under ambient conditions". supporting information. p. 6545 - 6548. Retrieved 2016/06/01.
• 2、 -. "6-Heteroarylpyridoindolone Derivatives, Their Preparation and Therapeutic Use Thereof". Page/Page column 13. . Retrieved 2008/12/04.