Pratol

Base Information

• Chemical Name: Pratol
• CAS No.: 487-24-1
• Molecular Formula: C16H12 O4
• Molecular Weight: 268.269
• European Community (EC) Number: 207-653-2
• NSC Number: 123414
• UNII: KU5R959MO7
• DSSTox Substance ID: DTXSID20197587
• Nikkaji Number: J94.480G
• Wikipedia: Pratol
• Wikidata: Q15424797
• Pharos Ligand ID: AVW6VNW2FAUJ
• Metabolomics Workbench ID: 74605
• ChEMBL ID: CHEMBL16751
• Mol file: 487-24-1.mol

Synonyms:Pratol;487-24-1;7-Hydroxy-4'-methoxyflavone;7-Hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one;7-hydroxy-2-(4-methoxyphenyl)chromen-4-one;7-Hydroxy-4-methoxyflavone;C.I. 75570;EINECS 207-653-2;4H-1-Benzopyran-4-one, 7-hydroxy-2-(4-methoxyphenyl)-;Flavone, 7-hydroxy-4'-methoxy-;NSC 123414;NSC-123414;BRN 0237239;UNII-KU5R959MO7;MLS002707301;KU5R959MO7;7-Hydroxy-2-(4-methoxyphenyl)-4-benzopyrone;NSC123414;7-Hydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one;487-17-2;5-18-04-00083 (Beilstein Handbook Reference);4hl5;7-Hydroxy-flavone, 5h;4'-methoxy-7-hydroxyflavone;Oprea1_854602;CHEMBL16751;SCHEMBL534596;BDBM85573;DTXSID20197587;TNP00065;MFCD00016937;AKOS004110700;CCG-208438;NCGC00017200-01;NCGC00017200-02;NCGC00017200-03;NCGC00142412-01;NCGC00142412-02;LS-39700;SMR001488172;CS-0148969;FT-0730316;Flavone, 7-hydroxy-4'-methoxy- (7CI,8CI);EN300-179336;AN-829/40761415;SR-05000002252;7-Hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one #;SR-05000002252-2;BRD-K35651673-001-05-9;Q15424797;Z1846974262;15W

Chemical Property of Pratol

Chemical Property:

• Vapor Pressure: 8.17E-10mmHg at 25°C
• Melting Point: 263-264°C
• Boiling Point: 479.4°Cat760mmHg
• Flash Point: 183.4°C
• PSA: 39.44000
• Density: 1.329g/cm³
• LogP: 3.77700
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 268.07355886
• Heavy Atom Count: 20
• Complexity: 395

Purity/Quality:

98%,99%, ^*data from raw suppliers

Pratol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C=C(C=C3)O

Technology Process of Pratol

There total 39 articles about Pratol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-<2-hydroxy-4-(methoxymethoxy)phenyl>-3-(4-methoxyphenyl)propane-1,3-dione (164031-41-8) → pratol (487-24-1)

Guidance literature:

With Amberlyst 15 resin; In isopropyl alcohol; for 12h; Heating;

Reference yield: 91.0%

1-(2',4'-dihydroxyphenyl)-3-(4''-methoxyphenyl)-propane-1,3-dione (75808-79-6) → pratol (487-24-1)

Guidance literature:

With sulfuric acid; acetic acid; for 1h; Reflux;

DOI:10.1039/c6ra17678j

Reference yield: 81.5%

2'-hydroxy-4'-(methoxymethoxy)-4-methoxychalcone (109471-14-9) → pratol (487-24-1)

Guidance literature:

With iodine; In dimethyl sulfoxide; at 160 ℃; for 0.333333h;

DOI:10.1016/j.ejmech.2017.02.037

upstream raw materials:

1-[2-hydroxy-4-(4-methoxy-benzoyloxy)-phenyl]-3-(4-methoxy-phenyl)-propane-1,3-dione

2',4'-dihydroxy-4-methoxychalcone

2',4'-bis(4-methoxybenzoyloxy)acetophenone

recorcinol

Downstream raw materials:

7-Allyloxy-2-(4-methoxy-phenyl)-chromen-4-one

7-hydroxy-2-(4-methoxy-phenyl)-4-oxo-4H-chromene-8-carbaldehyde

2-(4-methoxyphenyl)-7-(3-(4-(3-((1,2,3,4-tetrahydroacridin-9-yl)amino)propyl)piperazin-1-yl)propoxy)-4H-chromen-4-one

7-(3-bromopropoxy)-2-(4-methoxyphenyl)-4H-chromen-4-one

Refernces

• 1、 Padmini, Durbhaka S.,Prasad, S. V. U. M.,Swarnalatha, Dugasani. "Antioxidant and Cardioprotective Evaluation of Some N-(3-Chloro-2-oxo-4-arylazetidin-1-yl)-2-[(4-oxo-2-aryl-4H-chromen-7-yl)oxy]acetamide Derivatives". . p. 93 - 103. Retrieved 2022/01/08.
• 2、 Abdpour, Shahin,Jalili-Baleh, Leili,Nadri, Hamid,Forootanfar, Hamid,Bukhari, Syed Nasir Abbas,Ramazani, Ali,Ebrahimi, Seyed Esmaeil Sadat,Foroumadi, Alireza,Khoobi, Mehdi. "Chromone derivatives bearing pyridinium moiety as multi-target-directed ligands against Alzheimer's disease". . . Retrieved 2021/03/14.