2,4-Dimethoxyphenylacetic acid

Base Information

• Chemical Name: 2,4-Dimethoxyphenylacetic acid
• CAS No.: 6496-89-5
• Molecular Formula: C10H12O4
• Molecular Weight: 196.203
• Hs Code.: 29189900
• Mol file: 6496-89-5.mol

Synonyms:Aceticacid, (2,4-dimethoxyphenyl)- (6CI,7CI,8CI);(2,4-Dimethoxyphenyl)acetic acid;2,4-Dimethoxybenzeneacetic acid;2-(2,4-Dimethoxyphenyl)acetic acid;NSC 512596;2,4-Dimethoxyphenylacetic acid;

Chemical Property of 2,4-Dimethoxyphenylacetic acid

Chemical Property:

• Appearance/Colour: Crystalline Solid
• Vapor Pressure: 3.5E-05mmHg at 25°C
• Melting Point: 110-113 ºC
• Boiling Point: 339.7 °C at 760 mmHg
• PKA: 4.29±0.10(Predicted)
• Flash Point: 134.1 °C
• PSA: 55.76000
• Density: 1.189 g/cm³
• LogP: 1.33090
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

2,4-Dimethoxybenzeneacetic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38-36/37
• Safety Statements: 26-36-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A metabolite of dopamine analogs. Benzylamines and phenethylamines were converted to their analogous acids in the A metabolite of dopamine analogs. Benzylamines and phenethylamines were converted to their analogous acids in the metabolism of dopamine analogs.

Technology Process of 2,4-Dimethoxyphenylacetic acid

There total 22 articles about 2,4-Dimethoxyphenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

methyl 2-(2,4-dimethoxyphenyl)acetate (55954-25-1) → 2,4-dimethoxyphenylacetic acid (6496-89-5)

Guidance literature:

With sodium hydroxide; In ethanol; for 8h; Heating;

Reference yield: 62.0%

2',4'-dimethoxyacetophenone (829-20-9) → 2,4-dimethoxyphenylacetic acid (6496-89-5)

Guidance literature:

2',4'-dimethoxyacetophenone; With morpholine; sulfur; at 130 ℃; for 12h;

With sodium hydroxide; In water; for 12h; Reflux;

DOI:10.1080/00397911.2013.821616

Reference yield: 52.0%

2-chloro-1-(2,4-dimethoxyphenyl)ethanone (4783-90-8) → 1-chloro-2,4-dimethoxybenzene (7051-13-0) + 2,4-dimethoxyphenylacetic acid (6496-89-5) + 2',4'-dimethoxyacetophenone (829-20-9)

Guidance literature:

With methyloxirane; In water; acetonitrile; for 4h; Irradiation;

DOI:10.1016/S0040-4020(97)10081-3

upstream raw materials:

diazomethane

2-(2-hydroxy-4-methoxyphenyl)acetic acid

(2,4-dimethoxyphenyl)acetonitrile

(2,4-dimethoxy-phenyl)-acetic acid amide

Downstream raw materials:

6-hydroxy-2-oxo-3H-benzofuran-2-one

2,4-dimethoxy-phenethyl alcohol

(2,4-dimethoxy-phenyl)-acetic acid amide

2-<(2,4-dimethoxy)benzyl>-1H-imidazo<4,5-b>pyridine

Refernces

• 1、 Ji, Wen-Hua,Gao, Qian-Shan,Lin, Yun-Liang,Gao, Hong-Mei,Wang, Xiao,Geng, Yan-Ling. "Total synthesis of (±)-glabridin". . p. 540 - 546. Retrieved 2014/01/23.
• 2、 Bernier, David,Brueckner, Reinhard. "Novel synthesis of naturally occurring pulvinones: A heck coupling, transesterification, and Dieckmann condensation strategy". . p. 2249 - 2272. Retrieved 2008/03/12.