Methyl 2-(2,4-dimethoxyphenyl)acetate

Base Information

• Chemical Name: Methyl 2-(2,4-dimethoxyphenyl)acetate
• CAS No.: 55954-25-1
• Molecular Formula: C11H14O4
• Molecular Weight: 210.23
• DSSTox Substance ID: DTXSID90472853
• Nikkaji Number: J2.711.940I
• Wikidata: Q82302036
• Mol file: 55954-25-1.mol

Synonyms:Methyl 2-(2,4-dimethoxyphenyl)acetate;55954-25-1;2,4-DIMETHOXY-BENZENEACETIC ACID METHYL ESTER;MFCD09743316;methyl (2,4-dimethoxyphenyl)acetate;Benzeneacetic acid, 2,4-dimethoxy-, methyl ester;SCHEMBL4674015;DTXSID90472853;AKOS000296287;AS-32232;SY024628;CS-0187453;Methyl 2-(2 pound not4-Dimethoxyphenyl)acetate

Chemical Property of Methyl 2-(2,4-dimethoxyphenyl)acetate

Chemical Property:

• Boiling Point: 292.183 °C at 760 mmHg
• Flash Point: 125.281 °C
• PSA: 44.76000
• Density: 1.105g/cm³
• LogP: 1.41930
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 210.08920892
• Heavy Atom Count: 15
• Complexity: 205

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-(2,4-Dimethoxyphenyl)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)CC(=O)OC)OC

Technology Process of Methyl 2-(2,4-dimethoxyphenyl)acetate

There total 5 articles about Methyl 2-(2,4-dimethoxyphenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

methanol (67-56-1) + 2,4-dimethoxyphenylacetic acid (6496-89-5) → methyl 2-(2,4-dimethoxyphenyl)acetate (55954-25-1)

Guidance literature:

With sulfuric acid; for 3h; Reflux;

DOI:10.1021/acs.jafc.8b03830

Reference yield: 84.0%

methanol (67-56-1) + 2',4'-dimethoxyacetophenone (829-20-9) → methyl 2-(2,4-dimethoxyphenyl)acetate (55954-25-1)

Guidance literature:

With perchloric acid; thallium(III) nitrate; at 20 ℃; for 1h;

Reference yield:

(Z)-4-(2,4-dimethoxybenzylidene)-2-phenyl-4H-oxazol-5-one (118555-99-0) → methyl 2-(2,4-dimethoxyphenyl)acetate (55954-25-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 10percent aq. NaOH, 30percent H₂O₂

2: H₂SO₄

With sodium hydroxide; sulfuric acid; dihydrogen peroxide;

DOI:10.1016/0031-9422(88)80038-4

upstream raw materials:

methanol

2,4-dimethoxyphenylacetic acid

2',4'-dimethoxyacetophenone

(Z)-4-(2,4-dimethoxybenzylidene)-2-phenyl-4H-oxazol-5-one

Downstream raw materials:

methyl 2-(2,4-dimethoxyphenyl)-3-(2-O-methoxymethylphenyl)propanoate

methyl 2-(2,4-dimethoxyphenyl)-3-(4-methoxy-2-O-methoxymethylphenyl)propanoate

2,4-dimethoxyphenylacetic acid

methyl 3-(5-bromo-2,4-dimethoxy-phenyl)-2-(2,4-dimethoxy-phenyl)-3-oxo-propionate

Refernces

• 1、 -. "A MANUFACTURING PROCESS OF ISOFLAVAN OR ISOFLAVENE DERIVATIVES". Page/Page column 19. . Retrieved 2010/02/11.
• 2、 Alesso, E. N.,Aguirre, J. M.,Iglesias, G. Y. Moltrasio. "AN IMPROVED SYNTHESIS OF 2,4-DIMETHOXYPHENYLACETIC ACID". . p. 690 - 692. Retrieved 2007/10/03.