n-(7-Hydroxynaphthalen-1-yl)formamide

Base Information

• Chemical Name: n-(7-Hydroxynaphthalen-1-yl)formamide
• CAS No.: 7402-55-3
• Molecular Formula: C11H9 N O2
• Molecular Weight: 187.1947
• NSC Number: 55345
• DSSTox Substance ID: DTXSID40288340
• Wikidata: Q82024701
• Mol file: 7402-55-3.mol

Synonyms:n-(7-hydroxynaphthalen-1-yl)formamide;7402-55-3;NSC55345;8-formamido-2-naphthol;7-hydroxy-1-naphthylformamide;SCHEMBL9628490;DTXSID40288340;NHWKEOWEOKNTFL-UHFFFAOYSA-N;NSC-55345;AKOS024326391

Chemical Property of n-(7-Hydroxynaphthalen-1-yl)formamide

Chemical Property:

• Vapor Pressure: 3.24E-09mmHg at 25°C
• Boiling Point: 463.6°Cat760mmHg
• Flash Point: 234.2°C
• Density: 1.349g/cm³
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 187.063328530
• Heavy Atom Count: 14
• Complexity: 208

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=C(C=C2)O)C(=C1)NC=O

Technology Process of n-(7-Hydroxynaphthalen-1-yl)formamide

There total 3 articles about n-(7-Hydroxynaphthalen-1-yl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

8-amino-2-naphthol (118-46-7) + formamide (77287-34-4,77287-35-5,60100-09-6) → N-(7-hydroxy-[1]naphthyl)formamide (7402-55-3)

Guidance literature:

at 150 ℃; for 24h; Sealed tube; Green chemistry;

DOI:10.1021/acs.orglett.8b03542

Reference yield:

formic acid (64-18-6) + 8-amino-2-naphthol (118-46-7) → N-(7-hydroxy-[1]naphthyl)formamide (7402-55-3)

Guidance literature:

at 80 - 100 ℃;

Reference yield:

→ N-(7-hydroxy-[1]naphthyl)formamide (7402-55-3)

Guidance literature:

8-Amino-naphthol-(2), DMF, Natriummethylat;

DOI:10.1021/jo01351a623

upstream raw materials:

formic acid

8-amino-2-naphthol

formamide

Refernces

• 1、 -. "A non-catalyst non-promoter under the conditions of amide derivatives of aromatic amine with transfers the amine reaction". Paragraph 0075; 0076. . Retrieved 2019/03/28.