1,8-BIS(HYDROXYMETHYL)NAPHTHALENE

Base Information

• Chemical Name: 1,8-BIS(HYDROXYMETHYL)NAPHTHALENE
• CAS No.: 2026-08-6
• Molecular Formula: C12H12O2
• Molecular Weight: 188.226
• Hs Code.: 2906299090
• Mol file: 2026-08-6.mol

Synonyms:1,8-Bis(hydroxymethyl)naphthalene;1,8-Dihydroxymethylnaphthalene;

Chemical Property of 1,8-BIS(HYDROXYMETHYL)NAPHTHALENE

Chemical Property:

• Vapor Pressure: 1.7E-07mmHg at 25°C
• Melting Point: 153-156 °C(lit.)
• Refractive Index: 1.677
• Boiling Point: 411.1 °C at 760 mmHg
• PKA: 14.07±0.10(Predicted)
• Flash Point: 207.3 °C
• PSA: 40.46000
• Density: 1.244 g/cm³
• LogP: 1.82440
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

[8-(Hydroxymethyl)naphthalen-1-yl]methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1,8-Naphthalenedimethanol may be used in the synthesis of 1,8-bis-(chloromethyl)-naphthalene and 1,8-dimethylnaphthalene.

Technology Process of 1,8-BIS(HYDROXYMETHYL)NAPHTHALENE

There total 8 articles about 1,8-BIS(HYDROXYMETHYL)NAPHTHALENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1,8-Naphthalic anhydride (81-84-5) → naphthalene-1,8-diyldimethanol (2026-08-6)

Guidance literature:

With lithium aluminium tetrahydride; zinc(II) chloride; In tetrahydrofuran; at 20 ℃; for 6h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c6dt04484k

Reference yield: 77.0%

acenaphthene quinone (82-86-0) → naphthalene-1,8-diyldimethanol (2026-08-6)

Guidance literature:

With MoO₂Cl₂(H₂O)₂; phenylsilane; In tetrahydrofuran; for 16h; Reflux; Schlenk technique; Green chemistry;

DOI:10.1002/cctc.201500560

Reference yield: 53.0%

→ naphthalene-1,8-diyldimethanol (2026-08-6)

Guidance literature:

upstream raw materials:

1,8-Naphthalic anhydride

dimethyl naphthalene-1,8-dicarboxylate

Naphthalene-1,8-dicarboxylic acid

acenaphthene quinone

Downstream raw materials:

1,2-dibromoacenaphthene

3-phenyl-1H,5H-naphtho<1,8-ef><1,3>dithiocin

1,8-bis(mercaptomethyl)naphthalene

acenaphthylene

Refernces

• 1、 Beyler,Sarett. "-". . p. 1406,1411. Retrieved 1952.
• 2、 Luo, Huan,Zeng, Qingle,Liu, Zhongrong,Wei, Yongzhi,Li, Bogang,Wang, Fengpeng. "Mild and efficient synthesis of 1,8-naphthalide and 1,8- naphthalenedimethanol". . p. 2269 - 2275. Retrieved 2004.
• 3、 Chesnokov, Gleb A.,Topchiy, Maxim A.,Dzhevakov, Pavel B.,Gribanov, Pavel S.,Tukov, Aleksandr A.,Khrustalev, Victor N.,Asachenko, Andrey F.,Nechaev, Mikhail S.. "Eight-membered-ring diaminocarbenes bearing naphthalene moiety in the backbone: DFT studies, synthesis of amidinium salts, generation of free carbene, metal complexes, and solvent-free copper catalyzed azide-alkyne cycloaddition (CuAAC) reaction". supporting information. p. 4331 - 4345. Retrieved 2017/04/03.
• 4、 Zoń, Jerzy,Miziak, Piotr. "1-Aminobenzocyclobutene-1-phosphonic Acid and Related Compounds as Inhibitors of Phenylalanine Ammonia-Lyase". . . Retrieved 2017/05/17.