2-ethyl-4,4-diphenylpyrrolidine

Base Information

• Chemical Name: 2-ethyl-4,4-diphenylpyrrolidine
• CAS No.: 1033076-19-5
• Molecular Formula: C₁₈H₂₁N
• Molecular Weight: 251.371
• Mol file: 1033076-19-5.mol

Synonyms:2-ethyl-4,4-diphenylpyrrolidine

Chemical Property of 2-ethyl-4,4-diphenylpyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-ethyl-4,4-diphenylpyrrolidine

There total 3 articles about 2-ethyl-4,4-diphenylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-amino-2,2-diphenyl-4-hexene (53001-07-3) → 2-ethyl-4,4-diphenylpyrrolidine (1033076-19-5)

Guidance literature:

With C₄₈H₆₆N₂O₂Zr^(2-); trityl tetrakis(pentafluorophenyl)borate; In chlorobenzene; at 135 ℃; for 48h; Glovebox; Inert atmosphere;

DOI:10.1039/c5ra23270h

Reference yield: 88.0%

(E)-2,2-diphenyl-4-hexenyl-1-amine → 2-ethyl-4,4-diphenylpyrrolidine (1033076-19-5)

Guidance literature:

With (N,6-dimesityl-2-aminopyridinato)tris(dimethylamido)titanium; In ⁽²⁾H₈-toluene; at 110 ℃; for 48h; Inert atmosphere;

DOI:10.1021/om3012695

Reference yield: 83.0%

(E)-2,2-diphenyl-4-hexenyl-1-amine → 2-ethyl-4,4-diphenylpyrrolidine (1033076-19-5)

Guidance literature:

With tris(dimethylamido)(trityl(6-(tritylamino)pyridin-2-yl)amido)-titanium; In toluene; at 130 ℃; for 24h; regioselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1002/zaac.201500542

upstream raw materials:

1-amino-2,2-diphenyl-4-hexene

Downstream raw materials:

C₂₅H₂₅NO

Refernces

• 1、 Arrowsmith, Merle,Hill, Michael S.,Kociok-Koehn, Gabriele. "Suppression of Schlenk equilibration and heavier alkaline earth alkyl catalysis: A dearomatization strategy". . p. 1291 - 1294. Retrieved 2011.
• 2、 Arrowsmith, Merle,Hill, Michael S.,Kociok-Koehn, Gabriele. "Dearomatized BIAN alkaline-earth alkyl catalysts for the intramolecular hydroamination of hindered aminoalkenes". . p. 206 - 216. Retrieved 2014/02/14.