Technology Process of 1-(4-bromophenethyl)-N-(2-((2-ethoxyethyl)amino)phenyl)piperidine-4-carboxamide
There total 7 articles about 1-(4-bromophenethyl)-N-(2-((2-ethoxyethyl)amino)phenyl)piperidine-4-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(4-bromophenethyl)piperidine-4-carboxylic acid;
With
1-methyl-pyrrolidin-2-one; isobutyl chloroformate;
In
2-methyltetrahydrofuran;
at 0 - 5 ℃;
for 1.33333h;
Inert atmosphere;
N-(β-ethoxyethyl)-o-phenylenediamine;
In
2-methyltetrahydrofuran;
at 0 - 20 ℃;
for 21h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate; potassium iodide / 21 h / 80 °C / Inert atmosphere
2.1: sodium hydroxide; water / methanol / 20 °C
3.1: 1-methyl-pyrrolidin-2-one; isobutyl chloroformate / 2-methyltetrahydrofuran / 1.33 h / 0 - 5 °C / Inert atmosphere
3.2: 21 h / 0 - 20 °C
With
1-methyl-pyrrolidin-2-one; water; potassium carbonate; potassium iodide; sodium hydroxide; isobutyl chloroformate;
In
2-methyltetrahydrofuran; methanol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / 2-methyltetrahydrofuran; dimethyl sulfoxide / 23.5 h / 10 - 45 °C / Inert atmosphere
2.1: 5%-palladium/activated carbon; hydrogen / ethanol / 3 h / 5 - 10 °C / 2250.23 - 3000.3 Torr
3.1: 1-methyl-pyrrolidin-2-one; isobutyl chloroformate / 2-methyltetrahydrofuran / 1.33 h / 0 - 5 °C / Inert atmosphere
3.2: 21 h / 0 - 20 °C
With
1-methyl-pyrrolidin-2-one; 5%-palladium/activated carbon; hydrogen; potassium carbonate; isobutyl chloroformate;
In
2-methyltetrahydrofuran; ethanol; dimethyl sulfoxide;