Technology Process of 2-[(1R,3S,4S)-4-(2-Iodo-ethyl)-3-((S)-2-iodo-1-methyl-ethyl)-4-methyl-cyclohexyl]-propan-2-ol
There total 10 articles about 2-[(1R,3S,4S)-4-(2-Iodo-ethyl)-3-((S)-2-iodo-1-methyl-ethyl)-4-methyl-cyclohexyl]-propan-2-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 24 percent / potassium hydroxide, H2 / 10percent palladium charcoal / ethanol / 0.5 h / 760 Torr / Ambient temperature
2: 91 percent / pyridine / 44 h / Ambient temperature
3: 97 percent / basic alumina
4: 94 percent / LAH / diethyl ether / 12 h / Heating
5: 92 percent / chromium trioxide / pyridine / 3 h / Ambient temperature
6: 99 percent / boron trifluoride etherate / benzene / 4 h / Ambient temperature
7: 76 percent / etheral methyllithium / tetrahydrofuran / 0.33 h / 0 °C
8: 77 percent / ozone, sodium borohydride / methanol; CH2Cl2 / 0.58 h / -77 °C
9: 86 percent / pyridine / 72 h / Ambient temperature
10: NaI / acetone / 5 h / Heating
With
pyridine; chromium(VI) oxide; aluminum oxide; potassium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; methyllithium; hydrogen; ozone; sodium iodide;
palladium on activated charcoal;
In
tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; dichloromethane; acetone; benzene;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 97 percent / basic alumina
2: 94 percent / LAH / diethyl ether / 12 h / Heating
3: 92 percent / chromium trioxide / pyridine / 3 h / Ambient temperature
4: 99 percent / boron trifluoride etherate / benzene / 4 h / Ambient temperature
5: 76 percent / etheral methyllithium / tetrahydrofuran / 0.33 h / 0 °C
6: 77 percent / ozone, sodium borohydride / methanol; CH2Cl2 / 0.58 h / -77 °C
7: 86 percent / pyridine / 72 h / Ambient temperature
8: NaI / acetone / 5 h / Heating
With
pyridine; chromium(VI) oxide; aluminum oxide; sodium tetrahydroborate; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; methyllithium; ozone; sodium iodide;
In
tetrahydrofuran; pyridine; methanol; diethyl ether; dichloromethane; acetone; benzene;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 91 percent / pyridine / 44 h / Ambient temperature
2: 97 percent / basic alumina
3: 94 percent / LAH / diethyl ether / 12 h / Heating
4: 92 percent / chromium trioxide / pyridine / 3 h / Ambient temperature
5: 99 percent / boron trifluoride etherate / benzene / 4 h / Ambient temperature
6: 76 percent / etheral methyllithium / tetrahydrofuran / 0.33 h / 0 °C
7: 77 percent / ozone, sodium borohydride / methanol; CH2Cl2 / 0.58 h / -77 °C
8: 86 percent / pyridine / 72 h / Ambient temperature
9: NaI / acetone / 5 h / Heating
With
pyridine; chromium(VI) oxide; aluminum oxide; sodium tetrahydroborate; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; methyllithium; ozone; sodium iodide;
In
tetrahydrofuran; pyridine; methanol; diethyl ether; dichloromethane; acetone; benzene;