C₃₃H₄₆ClN₇O₅SSi

Base Information

• Chemical Name: C₃₃H₄₆ClN₇O₅SSi
• CAS No.: 1365271-58-4
• Molecular Formula: C₃₃H₄₆ClN₇O₅SSi
• Molecular Weight: 716.377
• Mol file: 1365271-58-4.mol

Synonyms:C₃₃H₄₆ClN₇O₅SSi

Chemical Property of C₃₃H₄₆ClN₇O₅SSi

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₃₃H₄₆ClN₇O₅SSi

There total 3 articles about C₃₃H₄₆ClN₇O₅SSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.1%

Diisopropylsilyl dichloride (7751-38-4) + 2-hydroxyethyl acrylate (818-61-1,9051-31-4,26022-14-0) + dasatanib (302962-49-8) → C33H46ClN7O5SSi (1365271-58-4)

Guidance literature:

Diisopropylsilyl dichloride; dasatanib; With 1H-imidazole; dmap; In N,N-dimethyl-formamide; for 1h; Inert atmosphere;

2-hydroxyethyl acrylate; In N,N-dimethyl-formamide; for 0.75h; Inert atmosphere;

Reference yield:

Diisopropylsilyl dichloride (7751-38-4) + dasatanib (302962-49-8) → C33H46ClN7O5SSi (1365271-58-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1H-imidazole; dmap / N,N-dimethyl-formamide / 0.25 h / Inert atmosphere

1.2: 0.75 h / Inert atmosphere

2.1: N,N-dimethyl-formamide / 0.75 h / Inert atmosphere

With 1H-imidazole; dmap; In N,N-dimethyl-formamide;

DOI:10.1021/ja301710z

Reference yield:

C28H39Cl2N7O2SSi + 2-hydroxyethyl acrylate (818-61-1,9051-31-4,26022-14-0) → C33H46ClN7O5SSi (1365271-58-4)

Guidance literature:

In N,N-dimethyl-formamide; for 0.75h; Inert atmosphere;

DOI:10.1021/ja301710z

upstream raw materials:

2-hydroxyethyl acrylate

Diisopropylsilyl dichloride

dasatanib

Refernces

• 1、 Parrott, Matthew C.,Finniss, Mathew,Luft, J. Chris,Pandya, Ashish,Gullapalli, Anuradha,Napier, Mary E.,Desimone, Joseph M.. "Incorporation and controlled release of silyl ether prodrugs from PRINT nanoparticles". supporting information; experimental part. p. 7978 - 7982. Retrieved 2012/06/18.