Diisopropyldichlorosilane

Base Information

• Chemical Name: Diisopropyldichlorosilane
• CAS No.: 7751-38-4
• Molecular Formula: C6H14Cl2Si
• Molecular Weight: 185.169
• Hs Code.: 29319090
• European Community (EC) Number: 629-177-8
• DSSTox Substance ID: DTXSID00374298
• Nikkaji Number: J364.752H
• Wikidata: Q82162827
• Mol file: 7751-38-4.mol

Synonyms:Dichlorodiisopropylsilane;dichloro[bis(1-methylethyl)]silane;

Chemical Property of Diisopropyldichlorosilane

Chemical Property:

• Vapor Pressure: 2.81mmHg at 25°C
• Melting Point: <0°C
• Refractive Index: n20/D 1.444
• Boiling Point: 162.6 °C at 760 mmHg
• Flash Point: 45.3 °C
• PSA: 0.00000
• Density: 0.991 g/cm³
• LogP: 3.72620
• Solubility.: sol most organic solvents.
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 2
• Exact Mass: 184.0241824
• Heavy Atom Count: 9
• Complexity: 79.1

Purity/Quality:

98% ^*data from raw suppliers

Diisopropyldichlorosilane ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 10-34
• Safety Statements: 28-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)[Si](C(C)C)(Cl)Cl
• Physical properties: bp 50–55°C/5 mmHg.
• Uses: Dichlorodiisopropylsilane can be used in nucleoside 3',5'-hydroxy protection; component in Peterson alkenation reaction.The use of silicon groups as protection for hydroxy groups has been widely exploited.3 One potentially useful way to protect a nucleoside is by using a protecting group which spans the 3- and 5-hydroxy groups. One of the useful groups which can be used as a bifunctional protecting group in nucleosides is the diisopropylsilyl group. Reaction of the nucleoside with dichlorodiisopropylsilane and imidazole in DMF gives the protected nucleoside (eq 1).This method has not been widely used; the more common 3',5'-hydroxy-bridging protecting group is a tetraisopropyldisiloxy group.

Technology Process of Diisopropyldichlorosilane

There total 7 articles about Diisopropyldichlorosilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

isopropylmagnesium chloride (1068-55-9) → Diisopropylsilyl dichloride (7751-38-4)

Guidance literature:

With tetrachlorosilane; In tetrahydrofuran; at 30 - 75 ℃; for 5h;

Reference yield:

isopropylmagnesium chloride (1068-55-9) → chlorotriisopropylsilane (6485-79-6) + Diisopropylsilyl dichloride (7751-38-4)

Guidance literature:

With tetrachlorosilane; In tetrahydrofuran; for 4h; Heating;

DOI:10.1016/j.jorganchem.2005.08.030

Reference yield:

isopropylmagnesium bromide (920-39-8) → 1,1,1-trichloro-2-methyl-1-silapropane (4170-46-1) + Diisopropylsilyl dichloride (7751-38-4)

Guidance literature:

With tetrachlorosilane; benzene;

DOI:10.1021/ja01170a600

upstream raw materials:

isopropyl chloride

isopropylmagnesium bromide

chlorodiisopropylsilane

isopropylmagnesium chloride

Downstream raw materials:

(chloromethyl)(diisopropyl)phenylsilane

3-[(4-Benzyloxy-phenyl)-diisopropyl-silanyloxy]-propan-1-ol

(4-tert-butyl-phenyl)-chloro-diisopropyl-silane

chloro-(4-ethyl-phenyl)-diisopropyl-silane

Refernces

• 1、 -. "Production processes for triorganomonoalkoxysilanes and triorganomonochlorosilanes". Page/Page column 29. . Retrieved 2008/06/13.