Hydrazinoacetic acid

Base Information

• Chemical Name: Hydrazinoacetic acid
• CAS No.: 14150-64-2
• Molecular Formula: C2H6 N2 O2
• Molecular Weight: 90.0818
• Hs Code.: 2928000090
• European Community (EC) Number: 237-995-8
• DSSTox Substance ID: DTXSID40161745
• Nikkaji Number: J216.883I
• Mol file: 14150-64-2.mol

Synonyms:hydrazinoacetic acid

Chemical Property of Hydrazinoacetic acid

Chemical Property:

• Vapor Pressure: 2.21E-06mmHg at 25°C
• Boiling Point: 366.8°C at 760 mmHg
• Flash Point: 175.6°C
• PSA: 75.35000
• Density: 1.311g/cm³
• LogP: -0.37450
• XLogP3: -3.5
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 90.042927438
• Heavy Atom Count: 6
• Complexity: 53.5

Purity/Quality:

98%Min ^*data from raw suppliers

2-HydrazinylaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(=O)O)NN
• Uses: 2-Hydrazinylacetic Acid is used as IL-17 and IFN-γ inhibitors for treating autoimmune diseases and chronic inflammation.

Technology Process of Hydrazinoacetic acid

There total 22 articles about Hydrazinoacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.9%

chloroacetic acid (79-11-8) → hydrazineacetic acid (14150-64-2)

Guidance literature:

With hydrazine hydrate; In dichloromethane; at 5 ℃; Temperature; Solvent;

Reference yield: 72.0%

2-((1,3-dioxoisoindolin-2-yl)amino)acetic acid → 2,3-dihydrophthalazine-1,4-dione (1445-69-8) + hydrazineacetic acid (14150-64-2)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1002/chem.202102593

Reference yield: 25.0%

2-((1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)amino)acetic acid → hydrazineacetic acid (14150-64-2) + 2-amino-1H-benzo[de]isoquinoline-1,3(2H)-dione (5690-46-0)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1002/chem.202102593

upstream raw materials:

diazoacetic acid

N-hydroxy-N-nitroso-glycine

semicarbazido-acetic acid

ethoxycarbonylhydrazono-acetic acid

Downstream raw materials:

2-semicarbazide acetic acid

2-hydrazinyl acetic acid ethyl ester hydrochloride

2-azidoacetic acid

3-(5-nitrofurfurylideneamino)hydantoic acid

Refernces

• 1、 Manoj Kumar, Mesram,Venkataramana, Parikibanda,Yadagiri Swamy, Parikibanda,Chityala, Yadaiah. "N-Amino-1,8-Naphthalimide is a Regenerated Protecting Group for Selective Synthesis of Mono-N-Substituted Hydrazines and Hydrazides". supporting information. p. 17713 - 17721. Retrieved 2021/11/10.
• 2、 -. "STRAIGHT-CHAIN AND BRANCHED-CHAIN LIPID COMPOUNDS AS SELECTIVE INHIBITORS OF CYCLOOXYGENASE-2, ANTI-INFLAMMATORY AGENTS, AND ANTI-CANCER AGENTS". Page/Page column 14-15. . Retrieved 2008/06/13.