C₁₃H₁₃F₃N₂O₃

Base Information

• Chemical Name: C₁₃H₁₃F₃N₂O₃
• CAS No.: 1354339-84-6
• Molecular Formula: C₁₃H₁₃F₃N₂O₃
• Molecular Weight: 302.253
• Mol file: 1354339-84-6.mol

Synonyms:C₁₃H₁₃F₃N₂O₃

Chemical Property of C₁₃H₁₃F₃N₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of C₁₃H₁₃F₃N₂O₃

There total 1 articles about C₁₃H₁₃F₃N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(R)-(-)-β-hydroxyvaline (2280-48-0,5174-30-1) + 4-fluoro-2-(trifluoromethyl)benzonitrile (194853-86-6) → C13H13F3N2O3 (1354339-84-6)

Guidance literature:

(R)-(-)-β-hydroxyvaline; 4-fluoro-2-(trifluoromethyl)benzonitrile; With potassium carbonate; In dimethyl sulfoxide; at 85 ℃; for 96h;

With citric acid; In water;

Reference yield: 95.0%

4-fluorobenzoyl hydrazide (456-06-4) + C13H13F3N2O3 (1354339-84-6) → C20H18F4N4O3 (1354339-86-8)

Guidance literature:

4-fluorobenzoyl hydrazide; C₁₃H₁₃F₃N₂O₃; In tetrahydrofuran; at -15 ℃; Inert atmosphere;

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; at -20 - 20 ℃;

Reference yield:

C13H13F3N2O3 (1354339-84-6) → (R)-4-(1-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxy-2-methylpropylamino)-2-(trifluoromethyl)benzonitrile (1354339-83-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / -15 °C / Inert atmosphere

1.2: -20 - 20 °C

2.1: triethylamine; triphenylphosphine; iodine / dichloromethane; tetrahydrofuran / 0.5 h / 0 °C

With iodine; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane;

upstream raw materials:

(R)-(-)-β-hydroxyvaline

4-fluoro-2-(trifluoromethyl)benzonitrile

Downstream raw materials:

(R)-4-(1-(5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxy-2-methylpropylamino)-2-(trifluoromethyl)benzonitrile

C₂₀H₁₈F₄N₄O₃

Refernces