Technology Process of Z-O-benzyltyrosylprolylphenylalanylprolylglycine benzyl ester
There total 7 articles about Z-O-benzyltyrosylprolylphenylalanylprolylglycine benzyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
TEA;
In
N,N-dimethyl-formamide;
for 48h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 78.8 percent / iBuOCOCl, N-methylmorpholine / tetrahydrofuran / 1.) -15 deg C, 30 min, 2.) 24 h, r.t.
2: 4N HCl / dioxane
3: 75 percent / TEA / dimethylformamide / 48 h
4: 4N HCl / dioxane
5: 89 percent / TEA / dimethylformamide / 48 h
6: 4N HCl / dioxane
7: 76 percent / TEA / dimethylformamide / 48 h
With
4-methyl-morpholine; hydrogenchloride; TEA; isobutyl chloroformate;
In
tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 4N HCl / dioxane
2: 75 percent / TEA / dimethylformamide / 48 h
3: 4N HCl / dioxane
4: 89 percent / TEA / dimethylformamide / 48 h
5: 4N HCl / dioxane
6: 76 percent / TEA / dimethylformamide / 48 h
With
hydrogenchloride; TEA;
In
1,4-dioxane; N,N-dimethyl-formamide;
