Sulfamethoxypyridazine

Base Information

• Chemical Name: Sulfamethoxypyridazine
• CAS No.: 80-35-3
• Molecular Formula: C11H12N4O3S
• Molecular Weight: 280.307
• Hs Code.: 29350090
• European Community (EC) Number: 201-272-5
• NSC Number: 757875
• UNII: T034E4NS2Z
• DSSTox Substance ID: DTXSID5023611
• Nikkaji Number: J9.115D
• Wikipedia: Sulfamethoxypyridazine
• Wikidata: Q7636177
• NCI Thesaurus Code: C80795
• Metabolomics Workbench ID: 66877
• ChEMBL ID: CHEMBL268869
• Mol file: 80-35-3.mol

Synonyms:Sulfamethoxypyridazine;Sulfapyridazine;Sulphamethoxypyridazine

Chemical Property of Sulfamethoxypyridazine

Chemical Property:

• Vapor Pressure: 8.8E-13mmHg at 25°C
• Melting Point: 182-183°
• Refractive Index: 1.646
• Boiling Point: 564.9 °C at 760 mmHg
• PKA: 6.7(at 25℃)
• Flash Point: 295.4 °C
• PSA: 115.58000
• Density: 1.465 g/cm³
• LogP: 2.60320
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: 579.5mg/L(25 oC)
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 4
• Exact Mass: 280.06301143
• Heavy Atom Count: 19
• Complexity: 376

Purity/Quality:

99% ^*data from raw suppliers

Sulfamethoxypyridazine-d3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NN=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)N
• Uses: Sulfamethoxypyridazine is a long-acting sulfonamide antibiotic with anti-inflammatory and antibacterial effects, mainly used for streptococcus, staphylococcus, Escherichia coli and other infections, especially for urinary tract infections.
• Indications: This drug possesses antibacterial activity with respect to a few cocci and colon bacillus. It is a long-lasting drug. It is used for treating pneumonia, bronchitis, tonsillitis, purulent otitis and meningitis, purulent infections of the urinary tract, dysentery, and others. Synonyms of this drug are sulfapyridazine, sufalex, retasulfin, and many others.

Technology Process of Sulfamethoxypyridazine

There total 4 articles about Sulfamethoxypyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methoxy-3-pyridazinamine (7252-84-8) + p-acetylaminobenzenesulfonyl chloride (121-60-8) → Sulfamethoxypyridazine (80-35-3)

Guidance literature:

6-methoxy-3-pyridazinamine; p-acetylaminobenzenesulfonyl chloride; With pyridine; In tetrahydrofuran; at 20 ℃; for 6h;

With sodium hydroxide; for 2h; Reflux;

DOI:10.1016/j.ejmech.2017.04.074

Reference yield:

4-acetylamino-N-(6-methoxy-pyridazin-3-yl)-benzenesulfonamide (127-75-3) → Sulfamethoxypyridazine (80-35-3)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01537a060

Reference yield:

sulfachloropyridazine (80-32-0) + sodium methylate (124-41-4) → Sulfamethoxypyridazine (80-35-3)

Guidance literature:

DOI:10.1021/ja01537a060

upstream raw materials:

sulfachloropyridazine

sodium methylate

4-acetylamino-N-(6-methoxy-pyridazin-3-yl)-benzenesulfonamide

6-methoxy-3-pyridazinamine

Downstream raw materials:

3-Sulfanilamido-6-oxopyridazine

4-[N'-(1-Acetyl-2-oxo-propylidene)-hydrazino]-N-(6-methoxy-pyridazin-3-yl)-benzenesulfonamide

N-(6-Methoxy-pyridazin-3-yl)-4-[3-oxo-3H-isobenzofuran-(1Z)-ylideneamino]-benzenesulfonamide

2-<4-sulphonamido-N¹-(6-methoxy-3-pyridazinyl)phenyl>amino-Δ²-thiazolin-4-one

Refernces

• 1、 -. "Process for formulating a synthetic drug for use in animal feed, and resulting formulation". . . Retrieved 2008/06/13.